Journal article
Role of arterial baroreceptor input on thirst and urinary responses to intracerebroventricular angiotensin II
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.265(3), pp.R591-R595
1993
DOI: 10.1152/ajpregu.1993.265.3.R591
Abstract
Intracerebroventricular (icv) infusion of angiotensin II (ANG II) in rats elicits greater water intake under hypotensive, compared with normotensive, conditions. The present experiments used sinoaortic baroreceptor-denervated (SAD) rats and sham-operated rats to examine if the modulatory effects of arterial blood pressure on water intake in response to icv ANG II are mediated by arterial baroreceptors. Mean arterial blood pressure (MAP) was raised or lowered by intravenous (i.v.) infusions of phenylephrine (1 or 10 micrograms.kg-1 x min-1) or minoxidil (25 micrograms.kg-1 x min-1), respectively. The angiotensin-converting enzyme inhibitor captopril (0.33 mg/min) was infused i.v. to prevent the endogenous formation of ANG II during testing. Urinary excretion of water and solutes was measured throughout. Water intake elicited by icv ANG II was inversely related to changes in MAP. Specifically, rats drank more water in response to icv ANG II when MAP was reduced by minoxidil but drank less water when MAP was elevated by phenylephrine. The influence of changing MAP on the icv ANG II-induced drinking responses was not affected by SAD. These results suggest that the modulatory effects of arterial blood pressure on icv ANG II-induced drinking can occur in the absence of sinoaortic baroreceptor input.
Details
- Title: Subtitle
- Role of arterial baroreceptor input on thirst and urinary responses to intracerebroventricular angiotensin II
- Creators
- Robert L Thunhorst - Univ. Iowa, cardiovascular cent., dep. psychology, Iowa 52242, United StatesStephen J Lewis - Univ. Iowa, cardiovascular cent., dep. psychology, Iowa 52242, United StatesAlan Kim Johnson - Univ. Iowa, cardiovascular cent., dep. psychology, Iowa 52242, United States
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.265(3), pp.R591-R595
- Publisher
- American Physiological Society
- DOI
- 10.1152/ajpregu.1993.265.3.R591
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Language
- English
- Date published
- 1993
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213407002771
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