Journal article
Role of central catecholamines in the control of blood pressure and drinking behavior
Brain research, Vol.178(1), pp.161-173
1979
DOI: 10.1016/0006-8993(79)90095-7
PMID: 497858
Abstract
The role of central nervous system (CNS) catecholamines in the development of hypertension and the control of drinking behavior was assessed in rats by depleting these amines with 6-hydroxydopamine (6-OHDA). Intraventricular administration of 6-OHDA completely prevented the development of one-kidney renal hypertension and abolished the associated increase in water consumption. 6-OHDA-treated rats showed deficits in drinking behavior when challenged with subcutaneous injections of angiotensin II (AII) and hypertonic sodium chloride. The acute pressor responses produced by intraventricular injections of AII and carbachol were virtually abolished by central catecholamine depletion. However, drinking produced by central cholinergic stimulation remained intact while AII drinking was significantly reduced.
These data demonstrate that the integrity of CNS catecholamines is required for the development of one-kidney renal hypertension and the increased drinking which accompanies it. In addition, destruction of central catecholamine-containing neurons allows for a specific dissociation of the pressor and drinking responses produced by central cholinergic but not AII stimulation.
Details
- Title: Subtitle
- Role of central catecholamines in the control of blood pressure and drinking behavior
- Creators
- Frank J GordonMichael J BrodyGregory D FinkJames BuggyAlan Kim Johnson
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.178(1), pp.161-173
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(79)90095-7
- PMID
- 497858
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1979
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213263602771
Metrics
15 Record Views