Role of chemoreceptors in mediating dyspnea

Gordon F Buchanan; George B Richerson

doi:10.1016/j.resp.2008.12.002

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Role of chemoreceptors in mediating dyspnea

Journal article

Peer reviewed

Role of chemoreceptors in mediating dyspnea

Gordon F Buchanan and George B Richerson

Respiratory physiology & neurobiology, Vol.167(1), pp.9-19

2009

DOI: 10.1016/j.resp.2008.12.002

PMCID: PMC4486073

PMID: 19118647

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http://doi.org/10.1016/j.resp.2008.12.002View

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Abstract

Dyspnea, or the uncomfortable awareness of respiratory distress, is a common symptom experienced by most people at some point during their lifetime. It is commonly encountered in individuals with pulmonary disease, such as chronic obstructive pulmonary disease (COPD), but can also be seen in healthy individuals after strenuous exercise, at altitude or in response to psychological stress. Dyspnea is a multifactorial sensation involving the brainstem, cortex, and limbic system, as well as mechanoreceptors, irritant receptors and chemoreceptors. Chemoreceptors appear to contribute to the sensation of dyspnea in two ways. They stimulate the respiratory control system in response to hypoxia and/or hypercapnia, and the resultant increase respiratory motor output can be consciously perceived as unpleasant. They also can induce the sensation of dyspnea through an as yet undetermined mechanism—potentially via direct ascending connections to the limbic system and cortex. The goal of this article is to briefly review how changes in blood gases reach conscious awareness and how chemoreceptors are involved in dyspnea.

Hypercapnia

Dyspnea

Serotonin

Hypoxia

Breathing

5-HT

Chemoreceptors

Raphe

Details

Title: Subtitle: Role of chemoreceptors in mediating dyspnea
Creators: Gordon F Buchanan - Department of Neurology, Yale University, School of Medicine, New Haven, CT 06520, United States
George B Richerson - Department of Neurology, Yale University, School of Medicine, New Haven, CT 06520, United States
Resource Type: Journal article
Publication Details: Respiratory physiology & neurobiology, Vol.167(1), pp.9-19
DOI: 10.1016/j.resp.2008.12.002
PMID: 19118647
PMCID: PMC4486073
NLM abbreviation: Respir Physiol Neurobiol
ISSN: 1569-9048
eISSN: 1878-1519
Publisher: Elsevier B.V
Language: English
Date published: 2009
Academic Unit: Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984020637702771

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