Role of collateral ventilation in ventilation-perfusion balance

Takayuki Kuriyama; Leonard P Latham; Lawrence D Horwitz; John T Reeves; Wiltz W Wagner Jr

doi:10.1152/jappl.1984.56.6.1500

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Role of collateral ventilation in ventilation-perfusion balance

Journal article

Peer reviewed

Role of collateral ventilation in ventilation-perfusion balance

Takayuki Kuriyama, Leonard P Latham, Lawrence D Horwitz, John T Reeves and Wiltz W Wagner Jr

Journal of applied physiology: respiratory, environmental and exercise physiology, Vol.56(6), pp.1500-1506

06/1984

DOI: 10.1152/jappl.1984.56.6.1500

PMID: 6735809

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Abstract

Species with collateral ventilation have an auxiliary respiratory mechanism that could protect them, under certain circumstances,from regional alveolar hypoxia. Species without collateral ventilation may have a greater potential for routinely experiencing regional hypoxia; to maintain ventilation-perfusion balance they would have to rely on pulmonary vasoconstriction. We tested these ideas by ventilating a sublobar region of pig lung (no collateral ventilation) with 13% O2 while the rest of the lung was ventilated with 30% Oz. Blood flow, as measured by radioactive microsphere distribution to the sublobar region, was reduced 50% during hypoxia. The hypoxia-induced vasoconstriction effectively defended arterial PO*. When a vasodilator was infused, regional blood flow increased to control levels; shunt fraction rose, and arterial PO2 fell. In dogs (collateral ventilation present) the same experimental maneuvers had no significant effect on regional end-tidal gasesor on microsphere distribution, indicating that collateral ventilation was able to maintain ventilation-perfusion balance. When regional hypoxia was created in dogs by overcoming collateral ventilation with slightly positive airway pressurein the sublobar region, the dog acted like the pig and used hypoxic vasoconstriction to shift -30% of the blood flow away from the hypoxic alveoli.

Air breathing

Biological and medical sciences

Fundamental and applied biological sciences. Psychology

Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics

Vertebrates: respiratory system

Details

Title: Subtitle: Role of collateral ventilation in ventilation-perfusion balance
Creators: Takayuki Kuriyama - University of Colorado Health
Leonard P Latham - University of Colorado Health
Lawrence D Horwitz - University of Colorado Health
John T Reeves - University of Colorado Health
Wiltz W Wagner Jr - University of Colorado Health
Resource Type: Journal article
Publication Details: Journal of applied physiology: respiratory, environmental and exercise physiology, Vol.56(6), pp.1500-1506
Publisher: American Physiological Society
DOI: 10.1152/jappl.1984.56.6.1500
PMID: 6735809
ISSN: 0161-7567
eISSN: 2691-2465
Language: English
Date published: 06/1984
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984656528702771

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