Journal article
Role of cytokines and chemokines in alcohol-induced tumor promotion
OncoTargets and therapy, Vol.10, pp.1665-1671
03/17/2017
DOI: 10.2147/OTT.S129781
PMCID: PMC5364014
PMID: 28360527
Abstract
Excessive chronic alcohol consumption has become a worldwide health problem. The oncogenic effect of chronic alcohol consumption is one of the leading concerns. The mechanisms of alcohol-induced tumorigenesis and tumor progression are largely unknown, although many factors have been implicated in the process. This review discusses the recent progress in this research area with concentration on alcohol-induced dysregulation of cytokines and chemokines. Based on the available evidence, we propose that alcohol promotes tumor progression by the dysregulation of the cytokine/chemokine system. In addition, we discuss specific transcription factors and signaling pathways that are involved in the action of these cytokines/chemokines and the oncogenic effect of alcohol. This review provides novel insight into the mechanisms of alcohol-induced tumor promotion.
Details
- Title: Subtitle
- Role of cytokines and chemokines in alcohol-induced tumor promotion
- Creators
- Danlei Chen - Anhui Medical UniversityFengyun Zhang - Anhui Medical UniversityHaifeng Ren - Anhui Medical UniversityJia Luo - University of KentuckySiying Wang - Anhui Medical University
- Resource Type
- Journal article
- Publication Details
- OncoTargets and therapy, Vol.10, pp.1665-1671
- DOI
- 10.2147/OTT.S129781
- PMID
- 28360527
- PMCID
- PMC5364014
- NLM abbreviation
- Onco Targets Ther
- ISSN
- 1178-6930
- eISSN
- 1178-6930
- Publisher
- Dove Medical Press
- Language
- English
- Date published
- 03/17/2017
- Academic Unit
- Pathology
- Record Identifier
- 9984201116202771
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