Role of elastin polymorphisms in panic disorder

Robert A Philibert; Jeffrey J Nelson; Bruce Bedell; Rhinda Goedken; Harinder K Sandhu; Russell Noyes Jr; Raymond R Crowe

doi:10.1002/ajmg.b.10014

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Role of elastin polymorphisms in panic disorder

Journal article

Peer reviewed

Role of elastin polymorphisms in panic disorder

Robert A Philibert, Jeffrey J Nelson, Bruce Bedell, Rhinda Goedken, Harinder K Sandhu, Russell Noyes Jr and Raymond R Crowe

American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.117B(1), pp.7-10

02/2003

DOI: 10.1002/ajmg.b.10014

PMID: 12555228

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Abstract

Panic disorder (PD) is a complex neuropsychiatric disorder that has been associated with an increased frequency of mitral valve prolapse. Elastin is a prominent component of mitral valves and, in a genome screen of 23 pedigrees with PD, we found evidence of linkage to the region of chromosome 7 that contains the elastin gene (ELN). Therefore, we examined the minimal essential promoter and coding regions of ELN in 23 independent probands from the families in our linkage studies using single strand conformational polymorphism analysis. We found three polymorphisms including one that coded for a non-conservative amino acid change. However, none of these polymorphisms were associated with panic disorder in a case-control analysis or linked to it in multiplex pedigrees. In our pedigrees, exonic polymorphisms in ELN do not play a major role in the genetic vulnerability to PD.

Promoter Regions, Genetic

Exons

Humans

Molecular Sequence Data

Family Health

DNA Primers

Case-Control Studies

Polymorphism, Genetic

Polymorphism, Single-Stranded Conformational

Elastin - genetics

Base Sequence

Genetic Linkage

Panic Disorder - genetics

Details

Title: Subtitle: Role of elastin polymorphisms in panic disorder
Creators: Robert A Philibert - Department of Psychiatry, The University of Iowa, Rm 2-205 Psychiatry Research/MEB, Iowa City, Iowa, USA. robert-philibert@uiowa.edu
Jeffrey J Nelson
Bruce Bedell
Rhinda Goedken
Harinder K Sandhu
Russell Noyes Jr
Raymond R Crowe
Resource Type: Journal article
Publication Details: American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.117B(1), pp.7-10
DOI: 10.1002/ajmg.b.10014
PMID: 12555228
NLM abbreviation: Am J Med Genet B Neuropsychiatr Genet
ISSN: 1552-4841
eISSN: 1552-485X
Publisher: United States
Grant note: MH 5KO2 MH00735 / NIMH NIH HHS
Language: English
Date published: 02/2003
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute
Record Identifier: 9984003968802771

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