Journal article
Role of genetics in the development of cardiac allograft vasculopathy
Bratislavské lékarské listy, Vol.124(3), pp.193-200
01/04/2023
DOI: 10.4149/BLL_2023_031
PMCID: PMC10517863
PMID: 36598310
Abstract
BACKGROUNDThe association between genetic polymorphisms and early cardiac allograft vasculopathy (CAV) development is relatively unexplored. Identification of genes involved in the CAV process may offer new insights into pathophysiology and lead to a wider range of therapeutic options. METHODSThis prospective study of 109 patients investigated 44 single nucleotide polymorphisms (SNPs) within the susceptibility loci potentially related to coronary artery disease, carotid artery intima-media thickness (cIMT), and in nitric oxide synthase gene. Genotyping was done by the Fluidigm SNP Type assays and Fluidigm 48.48 Dynamic Array IFC. The intima thickness progression (IT) was evaluated by coronary optical coherence tomography performed 1 month and 12 months after heart transplantation (HTx). RESULTSDuring the first post-HTx year, the mean intima thickness (IT) increased by 24.0 ± 34.2 µm (p < 0.001) and lumen area decreased by ‒0.9 ± 1.8 mm2 (p < 0.001). The rs1570360 (A/G) SNP of the vascular endothelial growth factor A (VEGFA) gene showed the strongest association with intima thickness progression, even in the presence of the traditional CAV risk factors. SNPs previously related to carotid artery intima-media thickness rs11785239 (PRAG1), rs6584389 (PAX2), rs13225723 (LINC02577) and rs17477177 (CCDC71L), were among the five most significantly associated with IT progression but lost their significance once traditional CAV risk factors had been added. CONCLUSIONResults of this study suggest that genetic variability may play an important role in CAV development. The vascular endothelial growth factor A gene SNP rs1570360 showed the strongest association with intima thickness (IT) progression measured by OCT, even in the presence of the traditional CAV risk factors (Tab. 3, Fig. 3, Ref. 36). Text in PDF www.elis.sk Keywords: cardiac allograft vasculopathy, optical coherence tomography, vascular endothelial growth factor A, intimal thickening, genetic polymorphism.
Details
- Title: Subtitle
- Role of genetics in the development of cardiac allograft vasculopathy
- Creators
- Lucie MayerovaAnna ChaloupkaPeter WohlfahrtJaroslav Alois HubacekHelena BedanovaZhi ChenJosef KautznerVojtech MelenovskyIvan MalekAles TomasekEva OzabalovaJan KrejciTomas KovarnikMilan SonkaMichal Pazdernik
- Resource Type
- Journal article
- Publication Details
- Bratislavské lékarské listy, Vol.124(3), pp.193-200
- DOI
- 10.4149/BLL_2023_031
- PMID
- 36598310
- PMCID
- PMC10517863
- NLM abbreviation
- Bratisl Lek Listy
- ISSN
- 0006-9248
- eISSN
- 1336-0345
- Language
- English
- Date published
- 01/04/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984358993702771
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