Journal article
Role of helminths in regulating mucosal inflammation
Springer seminars in immunopathology, Vol.27(2), pp.249-271
06/2005
DOI: 10.1007/s00281-005-0209-3
PMID: 15959781
Abstract
The rapid rise in prevalence of ulcerative colitis (UC) and Crohn’s disease (CD) in highly developed countries suggests that environmental change engenders risk for inflammatory bowel disease (IBD). Eradication of parasitic worms (helminths) through increased hygiene may be one such change that has led to increased prevalence of these diseases. Helminths alter host mucosal and systemic immunity, inhibiting dysregulated inflammatory responses. Animals exposed to helminths are protected from experimental colitis, encephalitis, and diabetes. Patients with CD or UC improve when exposed to whipworm. Lamina propria (LP) mononuclear cells from helminth-colonized mice make less interleukin (IL)-12 p40 and IFN-γ, but more IL-4, IL-13, IL-10, TGF-β, and PGE2 compared to LP mononuclear cells from naive mice. Systemic immune responses show similar skewing toward Th2 and regulatory cytokine production in worm-colonized animal models and humans. Recent reports suggest that helminths induce regulatory T cell activity. These effects by once ubiquitous organisms may have protected individuals from many of the emerging immune-mediated illnesses like IBD, multiple sclerosis, type I diabetes, and asthma.
Details
- Title: Subtitle
- Role of helminths in regulating mucosal inflammation
- Creators
- Joel Weinstock - Division of Gastroenterology–Hepatology (4607 JCP) University of Iowa Hospital and Clinics 200 Hawkins Drive Iowa City IA 52242-1009 USARobert Summers - Department of Internal Medicine, Division of Gastroenterology–Hepatology University of Iowa Iowa City IA 52242-1009 USADavid Elliott - Department of Internal Medicine, Division of Gastroenterology–Hepatology University of Iowa Iowa City IA 52242-1009 USA
- Resource Type
- Journal article
- Publication Details
- Springer seminars in immunopathology, Vol.27(2), pp.249-271
- Publisher
- Springer-Verlag
- DOI
- 10.1007/s00281-005-0209-3
- PMID
- 15959781
- ISSN
- 0344-4325
- eISSN
- 1432-2196
- Language
- English
- Date published
- 06/2005
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984094383502771
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