Role of redox reactions in the vascular phenotype of hyperhomocysteinemic animals

Sanjana Dayal; Steven R Lentz

doi:10.1089/ars.2007.1806

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Role of redox reactions in the vascular phenotype of hyperhomocysteinemic animals

Journal article

Peer reviewed

Role of redox reactions in the vascular phenotype of hyperhomocysteinemic animals

Sanjana Dayal and Steven R Lentz

Antioxidants & redox signaling, Vol.9(11), pp.1899-1909

11/2007

DOI: 10.1089/ars.2007.1806

PMID: 17822370

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Abstract

Hyperhomocysteinemia is a risk factor for cardiovascular disease, stroke, and thrombosis. Several animal models of hyperhomocysteinemia have been developed by using both dietary and genetic approaches. These animal models have provided considerable insight into the mechanisms underlying the adverse vascular effects of hyperhomocysteinemia. Accumulating evidence suggests a significant role of altered cellular redox reactions in the vascular phenotype of hyperhomocysteinemia. Redox effects of hyperhomocysteinemia are particularly important in mediating the adverse effects of hyperhomocysteinemia on the endothelium, leading to loss of endothelium-derived nitric oxide and vasomotor dysfunction. Redox reactions also may be key factors in the development of vascular hypertrophy, thrombosis, and atherosclerosis in hyperhomocysteinemic animals. In this review, we summarize the metabolic relations between homocysteine and the cellular redox state, the vascular phenotypes that have been observed in hyperhomocysteinemic animals, the evidence for altered redox reactions in vascular tissue, and the specific redox reactions that may mediate the vascular effects of hyperhomocysteinemia.

Cardiovascular Diseases - etiology

Hyperhomocysteinemia - blood

Oxidation-Reduction

Risk Factors

Endothelium, Vascular - physiopathology

Forecasting

Stroke - blood

Phenotype

Stroke - etiology

Animals

Endothelium, Vascular - metabolism

Models, Biological

Cardiovascular Diseases - blood

Coronary Thrombosis - etiology

Coronary Thrombosis - blood

Hyperhomocysteinemia - chemically induced

Hyperhomocysteinemia - complications

Disease Models, Animal

Details

Title: Subtitle: Role of redox reactions in the vascular phenotype of hyperhomocysteinemic animals
Creators: Sanjana Dayal - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
Steven R Lentz
Resource Type: Journal article
Publication Details: Antioxidants & redox signaling, Vol.9(11), pp.1899-1909
Publisher: United States
DOI: 10.1089/ars.2007.1806
PMID: 17822370
ISSN: 1523-0864
eISSN: 1557-7716
Grant note: HL63943 / NHLBI NIH HHS NS24621 / NINDS NIH HHS R01 HL063943 / NHLBI NIH HHS
Language: English
Date published: 11/2007
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984065397602771

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