Journal article
Role of renal nerves in sodium depletion-induced salt appetite
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.271(3), pp.R806-R812
09/01/1996
DOI: 10.1152/ajpregu.1996.271.3.R806
PMID: 8853406
Abstract
The ingestion of water and 0.3 M NaCl solution and the secretion of key hormones were studied in groups of intact and bilaterally renal-denervated rats after extracellular fluid depletion. Hypovolemia with mild hypotension was produced by subcutaneous injections of the diuretic furosemide (10 mg/kg) followed by injections of the angiotensin-converting enzyme inhibitor captopril (5 mg/kg s.c.). Denervated rats drank significantly less of a concentrated saline solution in response to depletion than intact control rats did, but drank similar amounts of water. Denervated rats finished testing in significantly greater negative water and sodium balance compared with controls. Renal denervation did not impair the secretion of renin and aldosterone or the formation of angiotensin I. The diminished sodium intake of denervated rats is not attributable to reduced water and sodium excretion in response to the hypovolemic protocol. These results indicate that the integrity of the renal nerves is important for the normal elaboration of salt appetite in response to hypovolemia/hypotension.
Details
- Title: Subtitle
- Role of renal nerves in sodium depletion-induced salt appetite
- Creators
- R. L Thunhorst - Department of Psychology and Pharmacology, University of Iowa, IowaCity 52242-1407, USAR. F Kirby - Department of Psychology and Pharmacology, University of Iowa, IowaCity 52242-1407, USAA. K Johnson - Department of Psychology and Pharmacology, University of Iowa, IowaCity 52242-1407, USA
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.271(3), pp.R806-R812
- DOI
- 10.1152/ajpregu.1996.271.3.R806
- PMID
- 8853406
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Language
- English
- Date published
- 09/01/1996
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; University College Courses; Health and Human Physiology
- Record Identifier
- 9984213406002771
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