Role of the Apparent Diffusion Coefficient as a Predictor of Tumor Progression in Patients with Chordoma

T. Sasaki; T. Moritani; A. Belay; A. A. Capizzano; S. P. Sato; Y. Sato; P. Kirby; S. Ishitoya; A. Oya; M. Toda; K. Takahashi

doi:10.3174/ajnr.A5664

Back

Role of the Apparent Diffusion Coefficient as a Predictor of Tumor Progression in Patients with Chordoma

Journal article

Open access

Peer reviewed

Role of the Apparent Diffusion Coefficient as a Predictor of Tumor Progression in Patients with Chordoma

T. Sasaki, T. Moritani, A. Belay, A. A. Capizzano, S. P. Sato, Y. Sato, P. Kirby, S. Ishitoya, A. Oya, M. Toda, …

American journal of neuroradiology : AJNR, Vol.39(7), pp.1316-1321

07/01/2018

DOI: 10.3174/ajnr.A5664

PMCID: PMC7655429

PMID: 29724767

Files and links (1)

url

https://doi.org/10.3174/ajnr.A5664View

Published (Version of record) Open Access

Abstract

BACKGROUND AND PURPOSE: Diffusion-weighted imaging may aid in distinguishing aggressive chordoma from nonaggressive chordoma. This study explores the prognostic role of the apparent diffusion coefficient in chordomas. MATERIALS AND METHODS: Sixteen patients with residual or recurrent chordoma were divided postoperatively into those with an aggressive tumor, defined as a growing tumor having a doubling time of <1 year, and those with a nonaggressive tumor on follow-up MR images. The ability of the ADC to predict an aggressive tumor phenotype was investigated by receiver operating characteristic analysis. The prognostic role of ADC was assessed using a Kaplan-Meier curve with a log-rank test. RESULTS: Seven patients died during a median follow-up of 48 months (range, 4-126 months). Five of these 7 patients were in the aggressive tumor group, and 2 were in the nonaggressive tumor group. The mean ADC was significantly lower in the aggressive tumor group than in the nonaggressive tumor group (P = .002). Receiver operating characteristic analysis showed that a cutoff ADC value of 1.494 x 10(-3) x mm(2)/s could be used to diagnose aggressive tumors with an area under the curve of 0.983 (95% CI, 0.911-1.000), a sensitivity of 1.000 (95% CI, 0.541-1.000), and a specificity of 0.900 (95% CI, 0.555-0.998). Furthermore, a cutoff ADC of 1.494 x 10(-3) x mm(2)/s was associated with a significantly worse prognosis (P = .006). CONCLUSIONS: Lower ADC values could predict tumor progression in postoperative chordomas.

Clinical Neurology

Life Sciences & Biomedicine

Neuroimaging

Neurosciences & Neurology

Radiology, Nuclear Medicine & Medical Imaging

Science & Technology

Details

Title: Subtitle: Role of the Apparent Diffusion Coefficient as a Predictor of Tumor Progression in Patients with Chordoma
Creators: T. Sasaki - From the Departments of Radiology (T.S., T.M., A.B., A.A.C., S.P.S., Y.S.).
T. Moritani - S&T (Czechia)
A. Belay - From the Departments of Radiology (T.S., T.M., A.B., A.A.C., S.P.S., Y.S.).
A. A. Capizzano - From the Departments of Radiology (T.S., T.M., A.B., A.A.C., S.P.S., Y.S.).
S. P. Sato - Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA
Y. Sato - From the Departments of Radiology (T.S., T.M., A.B., A.A.C., S.P.S., Y.S.).
P. Kirby - University of Iowa
S. Ishitoya - Asahikawa Medical University
A. Oya - Asahikawa Medical University
M. Toda - Asahikawa Medical University
K. Takahashi - Asahikawa Medical University
Resource Type: Journal article
Publication Details: American journal of neuroradiology : AJNR, Vol.39(7), pp.1316-1321
DOI: 10.3174/ajnr.A5664
PMID: 29724767
PMCID: PMC7655429
NLM abbreviation: AJNR Am J Neuroradiol
ISSN: 0195-6108
eISSN: 1936-959X
Publisher: Amer Soc Neuroradiology
Number of pages: 6
Grant note: JP15K19762 / Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
Language: English
Date published: 07/01/2018
Academic Unit: Radiology; Stead Family Department of Pediatrics; Pathology
Record Identifier: 9984318708502771

Metrics

40 Record Views

10 Times Cited - Web of Science

See more details