Journal article
Role of the M1 receptor in regulating circadian rhythms
Life sciences (1973), Vol.68(22-23), pp.2467-2472
04/2001
DOI: 10.1016/S0024-3205(01)01040-2
PMID: 11392614
Abstract
Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1–like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.
Details
- Title: Subtitle
- Role of the M1 receptor in regulating circadian rhythms
- Creators
- Martha U GilletteGordon F BuchananLiana ArtinianSusan E HamiltonNeil M NathansonChen Liu
- Resource Type
- Journal article
- Publication Details
- Life sciences (1973), Vol.68(22-23), pp.2467-2472
- DOI
- 10.1016/S0024-3205(01)01040-2
- PMID
- 11392614
- ISSN
- 0024-3205
- eISSN
- 1879-0631
- Language
- English
- Date published
- 04/2001
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984020775002771
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