Journal article
Role of the T Cell Receptor α Chain in Stabilizing TCR-Superantigen-MHC Class II Complexes
Immunity (Cambridge, Mass.), Vol.10(4), pp.473-483
1999
DOI: 10.1016/S1074-7613(00)80047-3
PMID: 10229190
Abstract
Superantigens (SAGs) activate T cells by simultaneously binding the Vβ domain of the TCR and MHC class II molecules on antigen-presenting cells. The preferential expression of certain Vα regions among SAG-reactive T cells has suggested that the TCR α chain may modulate the level of activation through an interaction with MHC. We demonstrate that the TCR α chain is required for maximum stabilization of the TCR-SAG-MHC complex and that the α chain increases the half-life of the complex to match those of TCR-peptide/MHC complexes. The site on the TCR α chain responsible for these effects is CDR2. Thus, the overall stability of the TCR-SAG-MHC complex is determined by the combination of three distinct interactions: TCR-SAG, SAG-MHC, and MHC-TCR.
Details
- Title: Subtitle
- Role of the T Cell Receptor α Chain in Stabilizing TCR-Superantigen-MHC Class II Complexes
- Creators
- Peter S Andersen - Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, Maryland 20850, USAPascal M Lavoie - Laboratoire d’Immunologie, Institut de Recherches Cliniques de Montréal, 110 avenue des Pins Ouest, Montréal, Québec H2W 1R7, CanadaRafick-Pierre Sékaly - Laboratoire d’Immunologie, Institut de Recherches Cliniques de Montréal, 110 avenue des Pins Ouest, Montréal, Québec H2W 1R7, CanadaHywyn Churchill - Department of Biochemistry, University of Illinois, Urbana, Illinois 61801, USADavid M Kranz - Department of Biochemistry, University of Illinois, Urbana, Illinois 61801, USAPatrick M Schlievert - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USAKlaus Karjalainen - Basel Institute for Immunology, Grenzacherstrasse 487, Postfach CH-4005 Basel, SwitzerlandRoy A Mariuzza - Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, Maryland 20850, USA
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.10(4), pp.473-483
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S1074-7613(00)80047-3
- PMID
- 10229190
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Language
- English
- Date published
- 1999
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984002386102771
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