Journal article
Role of the anterior region of the third ventricle in the cardiovascular responses produced by systemic injection of a nitric oxide synthase inhibitor
Brain research, Vol.830(1), pp.191-194
1999
DOI: 10.1016/S0006-8993(99)01351-7
PMID: 10350574
Abstract
This study examined whether a prior electrolytic lesion of the tissue surrounding the anteroventral third ventricle (AV3V) would affect the increase in mean arterial blood pressure (MAP) and the fall in heart rate (HR) produced by systemic injection of the nitric oxide synthesis (NOS) inhibitor,
N
G-nitro-
l-arginine methyl ester (
l-NAME; 25 μmol/kg, i.v.) in conscious rats.
l-NAME produced a smaller increase in MAP in AV3V-lesion than in sham-lesion rats (+19±3 vs. +40±3 mmHg, respectively;
P<0.05). In contrast,
l-NAME produced similar falls in HR in the AV3V-lesion and sham-lesion rats (−103±15 vs. −97±8 bpm, respectively;
P<0.05). These findings demonstrate that the
l-NAME-induced pressor response is dependent upon the integrity of the AV3V region, whereas the
l-NAME-induced bradycardia is not.
Details
- Title: Subtitle
- Role of the anterior region of the third ventricle in the cardiovascular responses produced by systemic injection of a nitric oxide synthase inhibitor
- Creators
- Stephen J Lewis - Department of Pharmacology, University of Iowa, Iowa City, IA, 52242-1407, USAErin J Whalen - Department of Pharmacology, University of Iowa, Iowa City, IA, 52242-1407, USATerry G Beltz - Department of Psychology, University of Iowa, 11 Seashore Hall E., Iowa City, IA, 52242-1407, USAAlan Kim Johnson - Department of Pharmacology, University of Iowa, Iowa City, IA, 52242-1407, USA
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.830(1), pp.191-194
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0006-8993(99)01351-7
- PMID
- 10350574
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1999
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213427802771
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