Journal article
Role of the anteroventral third ventricle (AV3V) region of the rat brain in the pressor response to γ2-melanocyte-stimulating hormone ( γ2-MSH)
Brain research, Vol.444(1), pp.177-180
1988
DOI: 10.1016/0006-8993(88)90925-0
Abstract
We have examined the role of the anteroventral third ventricle (AV3V) region of the forebrain on the pressor responses to intravenous injections of the pituitary pressor agent,
γ
2-melanocyte-stimulating hormone (
γ
2-MSH) and the direct acting
α
1-adrenergic agonist, phenylephrine in unanesthetized rats. Lesions of the AV3V region produce a parallel shift to the right in the dose response curve to
γ
2-MSH, with no effect on the pressor response to phenylephrine. The lesion had no effect on the heart rate response to either agent. These experiments indicate that the forebrain region surrounding the anterior third ventricle area is important to some of the cardiovascular actions of
γ
2-MSH.
Details
- Title: Subtitle
- Role of the anteroventral third ventricle (AV3V) region of the rat brain in the pressor response to γ2-melanocyte-stimulating hormone ( γ2-MSH)
- Creators
- Michael F Callahan - Department of Medicine, Section on Nephrology, Wake Forest University Medical Center, Winston-Salem, NC 27103 U.S.AJ.Thomas Cunningham - Department of Pharmacology, The University of Iowa, Iowa City, IA 52242 U.S.ARobert F Kirby - Department of Pharmacology, The University of Iowa, Iowa City, IA 52242 U.S.AAlan Kim Johnson - Department of Pharmacology, The University of Iowa, Iowa City, IA 52242 U.S.AKenneth A Gruber - Department of Medicine, Section on Nephrology, Wake Forest University Medical Center, Winston-Salem, NC 27103 U.S.A
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.444(1), pp.177-180
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(88)90925-0
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1988
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984214756002771
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