Role of the gut microbiota in age-related chronic inflammation

Tayyab Rehman

doi:10.2174/187153012803832620

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Journal article

Role of the gut microbiota in age-related chronic inflammation

Tayyab Rehman

Endocrine, metabolic & immune disorders drug targets, Vol.12(4), p.361

12/2012

DOI: 10.2174/187153012803832620

PMID: 23017185

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Abstract

Changing demographics have made aging and age-related chronic diseases an enormous and growing biomedical and societal challenge. The biological processes of aging may involve a role for the gut microbiota. Aspects of host physiology such as immune homeostasis and energy balance are profoundly influenced by the microbiota. Immune dysregulation characterizes old age and constitutes a major pathomechanism underlying frailty and age-associated chronic diseases. A growing body of literature implicates age-related perturbations in the gut microbial ecology as contributing to a global inflammatory state in the elderly. A better understanding of the nature and determinants of the host-microbe relationship in old age has the potential to translate into strategies that promote healthy aging and extend life span. This review summarizes our current understanding of the configuration of the age-related gut microbiota and its likely role in determining the immune phenotype in the elderly. It also highlights the specific components of the microbiota that can be targeted to modulate the age-related chronic inflammation.

Inflammation - microbiology

Humans

Gastrointestinal Tract - microbiology

Bacterial Load

Phylogeny

Metagenome - physiology

Prebiotics

Probiotics

Animals

Aging - physiology

RNA, Ribosomal, 16S - genetics

Chronic Disease

Inflammation - physiopathology

Details

Title: Subtitle: Role of the gut microbiota in age-related chronic inflammation
Creators: Tayyab Rehman - Department of Medicine, Louisiana State University Health Sciences Center, 1901 Perdido Street, MEB (Suite 3205), New Orleans, LA 70112, USA. trehma@lsuhsc.edu
Resource Type: Journal article
Publication Details: Endocrine, metabolic & immune disorders drug targets, Vol.12(4), p.361
DOI: 10.2174/187153012803832620
PMID: 23017185
NLM abbreviation: Endocr Metab Immune Disord Drug Targets
eISSN: 2212-3873
Language: English
Date published: 12/2012
Academic Unit: Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
Record Identifier: 9984094655602771

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