Role of voltage-sensitive calcium-channels in nitric oxide-mediated vasodilation in spontaneously hypertensive rats

Stephen J Lewis; Monica Y Bhopatkar; Tina M Walton; James N Bates

doi:10.1016/j.ejphar.2005.10.056

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Role of voltage-sensitive calcium-channels in nitric oxide-mediated vasodilation in spontaneously hypertensive rats

Journal article

Peer reviewed

Role of voltage-sensitive calcium-channels in nitric oxide-mediated vasodilation in spontaneously hypertensive rats

Stephen J Lewis, Monica Y Bhopatkar, Tina M Walton and James N Bates

European journal of pharmacology, Vol.528(1-3), pp.144-149

12/28/2005

DOI: 10.1016/j.ejphar.2005.10.056

PMID: 16321377

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Abstract

This study demonstrates that the vasodilator potencies of nitric oxide (NO) donors such as sodium nitroprusside are increased in conscious Spontaneously Hypertensive (SH) as compared to Wistar Kyoto (WKY) rats. For example, the NO donors do not dilate hindlimb resistance arteries in WKY rats whereas they elicit pronounced vasodilator responses in SH rats. This study also demonstrates that the NO-mediated vasodilator responses in WKY and SH rats were markedly diminished after blockade of voltage-sensitive Ca2+-channels (CaVS2+-channels) with nifedipine, diltiazem or verapamil. These findings suggest that NO dilates resistance arteries in vivo via direct and/or hyperpolarization-induced closure of CaVS2+-channels and that the increased potency of NO in SH rats may be due to the augmented CaVS2+-channel activity reported in this strain.

Animals

Blood Pressure - drug effects

Calcium Channel Blockers - pharmacology

Calcium Channels - drug effects

Calcium Channels - metabolism

Cysteine - analogs & derivatives

Cysteine - pharmacology

Diltiazem - pharmacology

Hindlimb

Hydrazines - pharmacology

Male

Muscle, Smooth, Vascular - drug effects

Muscle, Smooth, Vascular - metabolism

Nifedipine - pharmacology

Nitric Oxide - pharmacology

Nitric Oxide Donors - pharmacology

Nitroprusside - pharmacology

Rats

Rats, Inbred SHR

Rats, Inbred WKY

S-Nitrosothiols - pharmacology

Vascular Resistance - drug effects

Vasodilation - drug effects

Vasodilator Agents - pharmacology

Verapamil - pharmacology

Details

Title: Subtitle: Role of voltage-sensitive calcium-channels in nitric oxide-mediated vasodilation in spontaneously hypertensive rats
Creators: Stephen J Lewis - Case Western Reserve University
Monica Y Bhopatkar
Tina M Walton
James N Bates - University of Iowa, Anesthesia
Resource Type: Journal article
Publication Details: European journal of pharmacology, Vol.528(1-3), pp.144-149
DOI: 10.1016/j.ejphar.2005.10.056
PMID: 16321377
ISSN: 0014-2999
eISSN: 1879-0712
Grant note: HL-14388 / NHLBI NIH HHS
Language: English
Date published: 12/28/2005
Academic Unit: Anesthesia
Record Identifier: 9984424843002771

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