Journal article
Role of with-no-lysine [K] kinases in the pathogenesis of Gordon’s syndrome
Pediatric nephrology (Berlin, West), Vol.21(9), pp.1231-1236
09/2006
DOI: 10.1007/s00467-006-0106-6
PMID: 16683163
Abstract
Gordon’s syndrome, also known as pseudohypoaldosteronism type II (PHA II) or familial hypertension with hyperkalemia, is an autosomal-dominant disease characterized by hypertension, hyperkalemia, hyperchloremic metabolic acidosis, and normal glomerular filtration rate. Recent positional cloning has linked mutations of WNK1 and WNK4 to Gordon’s syndrome. With-no-lysine [K] (WNK) kinases are a new family of large serine–threonine protein kinases with an atypical placement of the catalytic lysine. Here, we review the pathogenesis of PHA II based on current understanding of the actions of WNK1 and WNK4 on Na+ and K+ handling in the renal distal tubule.
Details
- Title: Subtitle
- Role of with-no-lysine [K] kinases in the pathogenesis of Gordon’s syndrome
- Creators
- Jian Xie - Department of Medicine, Room J5-104, MC-8856 UT Southwestern Medical Center 5323 Harry Hines Blvd Dallas TX 75390-8856 USALeonard Craig - Department of Medicine, Room J5-104, MC-8856 UT Southwestern Medical Center 5323 Harry Hines Blvd Dallas TX 75390-8856 USAMelanie Cobb - Department Pharmacology University of Texas Southwestern Medical Center Dallas TX USAChou-Long Huang - Department of Medicine, Room J5-104, MC-8856 UT Southwestern Medical Center 5323 Harry Hines Blvd Dallas TX 75390-8856 USA
- Resource Type
- Journal article
- Publication Details
- Pediatric nephrology (Berlin, West), Vol.21(9), pp.1231-1236
- DOI
- 10.1007/s00467-006-0106-6
- PMID
- 16683163
- NLM abbreviation
- Pediatr Nephrol
- ISSN
- 0931-041X
- eISSN
- 1432-198X
- Publisher
- Springer-Verlag
- Language
- English
- Date published
- 09/2006
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094374602771
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