Journal article
Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functions
Cytokine & growth factor reviews, Vol.25(2), pp.147-156
04/2014
DOI: 10.1016/j.cytogfr.2013.12.002
PMCID: PMC3999169
PMID: 24433987
Abstract
TRAF3 is an adapter protein that serves and regulates the functions of several types of receptors, located both inside the cell and at the plasma membrane. These include members of the TNF receptor superfamily (TNFR-SF), toll-like receptors (TLR), and cytokine receptors. It has become increasingly evident that the roles and functions of TRAF3 are highly context-dependent. TRAF3 can serve distinct roles for different receptors in the same cell, and also has highly cell-type-dependent functions. This review focuses upon the current state of knowledge regarding how TRAF3 regulates the biology and effector functions of B and T lymphocytes, two major cell types of the adaptive immune response in which TRAF3 has markedly distinct roles.
Details
- Title: Subtitle
- Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functions
- Creators
- Zuoan Yi - Department of Microbiology, The University of Iowa, USAWai Wai Lin - The Graduate Program in Immunology, The University of Iowa, USALaura L Stunz - Department of Microbiology, The University of Iowa, USAGail A Bishop - Department of Microbiology, The University of Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Cytokine & growth factor reviews, Vol.25(2), pp.147-156
- DOI
- 10.1016/j.cytogfr.2013.12.002
- PMID
- 24433987
- PMCID
- PMC3999169
- NLM abbreviation
- Cytokine Growth Factor Rev
- ISSN
- 1359-6101
- eISSN
- 1879-0305
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Microbiology and Immunology; President
- Record Identifier
- 9984001142902771
Metrics
14 Record Views