Journal article
Roles for selenium and selenoprotein P in the development, progression, and prevention of intestinal disease
Free radical biology & medicine, Vol.127, pp.26-35
11/01/2018
DOI: 10.1016/j.freeradbiomed.2018.05.066
PMCID: PMC6168360
PMID: 29778465
Abstract
Selenium (Se) is a micronutrient essential to human health, the function of which is mediated in part by incorporation into a class of proteins known as selenoproteins (SePs). As many SePs serve antioxidant functions, Se has long been postulated to protect against inflammation and cancer development in the gut by attenuating oxidative stress. Indeed, numerous studies over the years have correlated Se levels with incidence and severity of intestinal diseases such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). Similar results have been obtained with the Se transport protein, selenoprotein P (SELENOP), which is decreased in the plasma of both IBD and CRC patients. While animal models further suggest that decreases in Se or SELENOP augment colitis and intestinal tumorigenesis, large-scale clinical trials have yet to show a protective effect in patient populations. In this review, we discuss the function of Se and SELENOP in intestinal diseases and how research into these mechanisms may impact patient treatment.
Details
- Title: Subtitle
- Roles for selenium and selenoprotein P in the development, progression, and prevention of intestinal disease
- Creators
- Sarah P. Short - Vanderbilt University Medical CenterJennifer M. Pilat - Vanderbilt UniversityChristopher S. Williams - Vanderbilt University Medical Center
- Resource Type
- Journal article
- Publication Details
- Free radical biology & medicine, Vol.127, pp.26-35
- Publisher
- Elsevier
- DOI
- 10.1016/j.freeradbiomed.2018.05.066
- PMID
- 29778465
- PMCID
- PMC6168360
- ISSN
- 0891-5849
- eISSN
- 1873-4596
- Number of pages
- 10
- Grant note
- R01DK099204; P30DK058404; F32 DK108492; UL1TR000445 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 1I01BX001426 / Office of Medical Research, Department of Veterans Affairs; US Department of Veterans Affairs P30DK058404 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) F31CA165667 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) UL1TR002243 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) I01BX001426 / Veterans Affairs; US Department of Veterans Affairs
- Language
- English
- Date published
- 11/01/2018
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984420847102771
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