Roles of BCCIP in chromosome stability and cytokinesis

X Meng; J Fan; Z Shen

doi:10.1038/sj.onc.1210460

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Roles of BCCIP in chromosome stability and cytokinesis

Journal article

Open access

Peer reviewed

Roles of BCCIP in chromosome stability and cytokinesis

X Meng, J Fan and Z Shen

Oncogene, Vol.26(43), pp.6253-6260

09/20/2007

DOI: 10.1038/sj.onc.1210460

PMCID: PMC2667889

PMID: 17452982

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http://doi.org/10.1038/sj.onc.1210460View

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Abstract

The BRCA2 gene is involved in recombinational DNA repair and cytokinesis. BRCA2 defects are associated with chromosomal abnormalities, which is a hallmark of genomic instability that contributes to tumorigenesis. Here, we show that downregulation of a BRCA2 interacting protein (BCCIP) in HT1080 cells leads to chromosomal polyploidization, centrosome amplification and abnormal mitotic spindle formation. The BCCIP knockdown cells can enter mitosis and retain spindle checkpoint, but fail to complete cytokinesis. Our data suggest an essential role of BCCIP in the maintenance of genomic integrity.

BCCIP

polyploidy

BRCA2

cytokinesis

chromosome instability

Details

Title: Subtitle: Roles of BCCIP in chromosome stability and cytokinesis
Creators: X Meng - Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
J Fan - Department of Radiation Oncology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA
Z Shen - Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
Resource Type: Journal article
Publication Details: Oncogene, Vol.26(43), pp.6253-6260
DOI: 10.1038/sj.onc.1210460
PMID: 17452982
PMCID: PMC2667889
NLM abbreviation: Oncogene
ISSN: 0950-9232
eISSN: 1476-5594
Language: English
Date published: 09/20/2007
Academic Unit: Pathology
Record Identifier: 9984047708902771

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