Journal article
Roles of Estrogen in the Formation of Intracranial Aneurysms in Ovariectomized Female Mice
Neurosurgery, Vol.75(6), pp.690-695
12/01/2014
DOI: 10.1227/NEU.0000000000000528
PMCID: PMC4399640
PMID: 25181430
Abstract
Abstract
Background:
Epidemiological studies have indicated that postmenopausal women have a higher incidence of intracranial aneurysms than men in the same age group.
Objective:
To investigate whether estrogen or estrogen receptors (ERs) mediate protective effects against the formation of intracranial aneurysms.
Methods:
Intracranial aneurysms were induced in mice by combining a single injection of elastase into the cerebrospinal fluid with deoxycorticosterone acetate salt hypertension. The mice were treated with estrogen (17β-estradiol), an ERα agonist (propyl pyrazole triol), and an ERβ agonist (diarylpropionitrile) with and without a nitric oxide synthase inhibitor.
Results:
The ovariectomized female mice had a significantly higher incidence of aneurysms than the male mice, which was consistent with findings in previous epidemiological studies. In ovariectomized female mice, an ERβ agonist, but not an ERα agonist or 17β-estradiol, significantly reduced the incidence of aneurysms. The protective effect of the ERβ agonist was absent in the ovariectomized ERβ knockout mice. The protective effect of the ERβ agonist was negated by treatment with a nitric oxide synthase inhibitor.
Conclusion:
The effects of sex, menopause, and estrogen treatment observed in this animal study were consistent with previous epidemiological findings. Stimulation of estrogen receptor-β was protective against the formation of intracranial aneurysms in ovariectomized female mice.
Details
- Title: Subtitle
- Roles of Estrogen in the Formation of Intracranial Aneurysms in Ovariectomized Female Mice
- Creators
- Yoshiteru Tada - ‡Department of Anesthesia and Perioperative CareHiroshi Makino - ‡Department of Anesthesia and Perioperative CareHajime Furukawa - ‡Department of Anesthesia and Perioperative CareKenji Shimada - ‡Department of Anesthesia and Perioperative CareKosuke Wada - ‡Department of Anesthesia and Perioperative CareElena I Liang - ‡Department of Anesthesia and Perioperative CareShoko Murakami - ‡Department of Anesthesia and Perioperative CareMari Kudo - ‡Department of Anesthesia and Perioperative CareDavid K Kung - ¶Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IowaDavid M Hasan - §Department of Neurological Surgery, University of California, San Francisco, CaliforniaKeiko T Kitazato - ‖Department of Neurosurgery, School of Medicine, University of Tokushima, Tokushima City, JapanShinji Nagahiro - ‖Department of Neurosurgery, School of Medicine, University of Tokushima, Tokushima City, JapanMichael T Lawton - §Department of Neurological Surgery, University of California, San Francisco, CaliforniaTomoki Hashimoto - ‡Department of Anesthesia and Perioperative Care
- Resource Type
- Journal article
- Publication Details
- Neurosurgery, Vol.75(6), pp.690-695
- DOI
- 10.1227/NEU.0000000000000528
- PMID
- 25181430
- PMCID
- PMC4399640
- NLM abbreviation
- Neurosurgery
- ISSN
- 0148-396X
- eISSN
- 1524-4040
- Publisher
- Oxford University Press
- Language
- English
- Date published
- 12/01/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurosurgery; Otolaryngology
- Record Identifier
- 9984040394802771
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