Roles of Rho GTPases in Intracellular Transport and Cellular Transformation

Xiaojuan Chi; Song Wang; Yifan Huang; Mark Stamnes; Ji-Long Chen

doi:10.3390/ijms14047089

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Roles of Rho GTPases in Intracellular Transport and Cellular Transformation

Journal article

Open access

Peer reviewed

Roles of Rho GTPases in Intracellular Transport and Cellular Transformation

Xiaojuan Chi, Song Wang, Yifan Huang, Mark Stamnes and Ji-Long Chen

International journal of molecular sciences, Vol.14(4), pp.7089-7108

04/2013

DOI: 10.3390/ijms14047089

PMCID: PMC3645678

PMID: 23538840

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Abstract

Rho family GTPases belong to the Ras GTPase superfamily and transduce intracellular signals known to regulate a variety of cellular processes, including cell polarity, morphogenesis, migration, apoptosis, vesicle trafficking, viral transport and cellular transformation. The three best-characterized Rho family members are Cdc42, RhoA and Rac1. Cdc42 regulates endocytosis, the transport between the endoplasmic reticulum and Golgi apparatus, post-Golgi transport and exocytosis. Cdc42 influences trafficking through interaction with Wiskott-Aldrich syndrome protein (N-WASP) and the Arp2/3 complex, leading to changes in actin dynamics. Rac1 mediates endocytic and exocytic vesicle trafficking by interaction with its effectors, PI3kinase, synaptojanin 2, IQGAP1 and phospholipase D1. RhoA participates in the regulation of endocytosis through controlling its downstream target, Rho kinase. Interestingly, these GTPases play important roles at different stages of viral protein and genome transport in infected host cells. Importantly, dysregulation of Cdc42, Rac1 and RhoA leads to numerous disorders, including malignant transformation. In some cases, hyperactivation of Rho GTPases is required for cellular transformation. In this article, we review a number of findings related to Rho GTPase function in intracellular transport and cellular transformation.

actin cytoskeleton

cellular transformation

Rho GTPases

Review

viral transport

vesicle trafficking

Details

Title: Subtitle: Roles of Rho GTPases in Intracellular Transport and Cellular Transformation
Creators: Xiaojuan Chi - College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; E-Mails
Song Wang - CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100101, China; E-Mail
Yifan Huang - College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; E-Mails
Mark Stamnes - Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; E-Mail
Ji-Long Chen - College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; E-Mails
Resource Type: Journal article
Publication Details: International journal of molecular sciences, Vol.14(4), pp.7089-7108
DOI: 10.3390/ijms14047089
PMID: 23538840
PMCID: PMC3645678
NLM abbreviation: Int J Mol Sci
ISSN: 1661-6596
eISSN: 1422-0067
Publisher: Molecular Diversity Preservation International (MDPI)
Language: English
Date published: 04/2013
Academic Unit: Molecular Physiology and Biophysics; Internal Medicine
Record Identifier: 9984025347402771

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