Journal article
Roles of cancer/testis antigens (CTAs) in breast cancer
Cancer letters, Vol.399, pp.64-73
07/28/2017
DOI: 10.1016/j.canlet.2017.02.031
PMID: 28274891
Abstract
Breast cancer is the most common cancer diagnosed and is the second leading cause of cancer death among women in the US. For breast cancer, early diagnosis and efficient therapy remains a significant clinical challenge. Therefore, it is necessary to identify novel tumor associated molecules to target for biomarker development and immunotherapy. In this regard, cancer testis antigens (CTAs) have emerged as a potential clinical biomarker targeting immunotherapy for various malignancies due to the nature of its characteristics. CTAs are a group of tumor associated antigens (TAAs) that display normal expression in immune-privileged organs, but display aberrant expression in several types of cancers, particularly in advanced cancers. Investigation of CTAs for the clinical management of breast malignancies indicates that these TAAs have potential roles as novel biomarkers, with increased specificity and sensitivity compared to those currently used in the clinic. Moreover, TAAs could be therapeutic targets for cancer immunotherapy. This review is an attempt to address the promising CTAs in breast cancer and their possible clinical implications as biomarkers and immunotherapeutic targets with particular focus on challenges and future interventions.
•CTAs were previously reported to be a potential treatment target in many malignant tumors.•The immunogenic nature of CTAs makes them excellent targets for cancer immunotherapy and early detection.•The function and mechansim of CTAs in breast cancer development are worthy for attention.
Details
- Title: Subtitle
- Roles of cancer/testis antigens (CTAs) in breast cancer
- Creators
- Yongfei Li - Nanjing Medical UniversityJun Li - Nanjing Medical UniversityYifan Wang - Nanjing Medical UniversityYanhong Zhang - Nanjing Medical UniversityJiahui Chu - Nanjing Medical UniversityChunxiao Sun - Nanjing Medical UniversityZiyi Fu - Nanjing Medical UniversityYi Huang - Magee-Womens Research InstituteHansheng Zhang - University of Maryland, College ParkHongyan Yuan - Georgetown University Medical CenterYongmei Yin - Nanjing Medical University
- Resource Type
- Journal article
- Publication Details
- Cancer letters, Vol.399, pp.64-73
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.canlet.2017.02.031
- PMID
- 28274891
- ISSN
- 0304-3835
- eISSN
- 1872-7980
- Grant note
- DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 81172503, 81572603, 81302304, 81402139
- Language
- English
- Date published
- 07/28/2017
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984383916302771
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