Journal article
Roles of interleukin-11 during acute bacterial pneumonia
PloS one, Vol.14(8), pp.e0221029-e0221029
08/15/2019
DOI: 10.1371/journal.pone.0221029
PMCID: PMC6695241
PMID: 31415618
Abstract
Interleukin-11 (IL-11) is an interleukin-6 (IL-6) family cytokine shown to play a protective role in acute inflammatory settings including systemic infection. In this study we addressed the role of IL-11 in acute bacterial pneumonia using a mouse model of E. coli pneumonia. Compared with other related cytokines, IL-11 protein was maintained at high levels in the lung at baseline, with only mild alterations in whole lung and BALF levels during acute infection. The primary source of IL-11 in the lung was the epithelium, but steady state production was not dependent on the inflammatory transcription factor nuclear factor kappa B in cells of either myeloid or epithelial lineage. Blockade of IL-11 with neutralizing antibodies resulted in a mild but significant decrease in neutrophil recruitment and increase in pulmonary edema during pneumonia, without detectable alterations in bacterial clearance. Exogenous IL-11 administration, however, had no effect at baseline or during infection. Overall, we conclude that maintenance of lung IL-11 concentrations may influence acute pulmonary inflammation during infection, albeit modestly.
Details
- Title: Subtitle
- Roles of interleukin-11 during acute bacterial pneumonia
- Creators
- Katrina E. Traber - Boston UniversityErnest L. Dimbo - Boston UniversityElise M. Symer - Boston UniversityFiliz T. Korkmaz - Boston UniversityMatthew R. Jones - Boston UniversityJoseph P. Mizgerd - Boston UniversityLee J. Quinton - Boston University
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.14(8), pp.e0221029-e0221029
- Publisher
- Public Library Science
- DOI
- 10.1371/journal.pone.0221029
- PMID
- 31415618
- PMCID
- PMC6695241
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Number of pages
- 16
- Grant note
- T32 HL-007035; K08 HL-130582; R01 HL-111449; R01 GM-120060; R01 HL-136725; R35 HL-135756 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA KL2 TR-001411 / National Center for Advancing Translational Sciences, National Institutes of Health, through BU-CTSI Grant
- Language
- English
- Date published
- 08/15/2019
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984696654502771
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