Journal article
Roles of the apparent diffusion coefficient and tumor volume in predicting tumor grade in patients with choroid plexus tumors
Neuroradiology, Vol.60(5), pp.479-486
05/2018
DOI: 10.1007/s00234-018-2008-2
PMID: 29546484
Abstract
To explore the utility of the apparent diffusion coefficient (ADC) and tumor volume to predict histological grade and prognosis in patients with choroid plexus tumors. ADC and tumor volumes were retrospectively evaluated in 25 patients with choroid plexus papilloma (CPP; WHO grade 1 [n = 13]), atypical CPP (aCPP; grade 2 [n = 8]), or choroid plexus carcinoma (grade 3 [n = 4]) The prognostic roles of ADC and tumor volume were assessed. There were significant differences in mean and minimum ADC values, and tumor volume among the WHO grades (p = 0.033, p = 0.044, and p = 0.014, respectively). Receiver-operating characteristic analysis revealed a mean cutoff ADC value ≤ 1.397 × 10 mm /s for aCPP (sensitivity = 0.667, specificity = 0.923). Multiple linear regression analysis demonstrated that both mean ADC (β = - 0.455, p = 0.005) and tumor volume (β = 0.513, p = 0.002) were correlated with WHO grade (adjusted R = 0.520, p = 0.005). Kaplan-Meier curve analysis identified poorer survival in patients with WHO grade 2 and 3 tumors than in those with WHO grade 1 disease (p = 0.049 and p = 0.012, respectively). A mean ADC ≤ 1.397 × 10 mm /s (p = 0.001) and tumor volume 21.05 ml (p = 0.031) predicted significantly poorer survival. Mean ADC and tumor volume were correlated with WHO grade of choroid plexus tumors. A lower ADC value and a larger tumor volume predicted a poorer prognosis.
Details
- Title: Subtitle
- Roles of the apparent diffusion coefficient and tumor volume in predicting tumor grade in patients with choroid plexus tumors
- Creators
- Tomoaki Sasaki - Department of Radiology, Asahikawa Medical University, 2-1-1-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, Japan. tomoaki3est@gmail.comJohn Kim - Department of Radiology, University of Michigan, 1500 E. Medical Center Dr, Ann Arbor, MI, 48109, USAToshio Moritani - Department of Radiology, University of Michigan, 1500 E. Medical Center Dr, Ann Arbor, MI, 48109, USAAristides A Capizzano - Department of Radiology, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USAShawn P Sato - Department of Radiology, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USAYutaka Sato - Department of Radiology, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USAPatricia Kirby - Department of Pathology, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USAShunta Ishitoya - Department of Radiology, Asahikawa Medical University, 2-1-1-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, JapanAkiko Oya - Department of Radiology, Asahikawa Medical University, 2-1-1-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, JapanMasahiro Toda - Department of Radiology, Asahikawa Medical University, 2-1-1-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, JapanSayaka Yuzawa - Department of Diagnostic Pathology, Asahikawa Medical University Hospital, 2-1-1-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, JapanKoji Takahashi - Department of Radiology, Asahikawa Medical University, 2-1-1-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, Japan
- Resource Type
- Journal article
- Publication Details
- Neuroradiology, Vol.60(5), pp.479-486
- Publisher
- Germany
- DOI
- 10.1007/s00234-018-2008-2
- PMID
- 29546484
- ISSN
- 0028-3940
- eISSN
- 1432-1920
- Grant note
- JP15K19762 / Japan Society for the Promotion of Science
- Language
- English
- Date published
- 05/2018
- Academic Unit
- Radiology; Pathology
- Record Identifier
- 9983905640202771
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