Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions

Joanne M Hildebrand; Zuoan Yi; Claire M Buchta; Jayakumar Poovassery; Laura L Stunz; Gail A Bishop

doi:10.1111/j.1600-065X.2011.01055.x

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Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions

Journal article

Open access

Peer reviewed

Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions

Joanne M Hildebrand, Zuoan Yi, Claire M Buchta, Jayakumar Poovassery, Laura L Stunz and Gail A Bishop

Immunological reviews, Vol.244(1), pp.55-74

11/2011

DOI: 10.1111/j.1600-065X.2011.01055.x

PMCID: PMC3202299

PMID: 22017431

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Abstract

A large and diverse group of receptors utilizes the family of cytoplasmic signaling proteins known as tumor necrosis factor receptor (TNFR)-associated factors (TRAFs). In recent years, there has been a resurgence of interest and exploration of the roles played by TRAF3 and TRAF5 in cellular regulation, particularly in cells of the immune system, the cell types of focus in this review. This work has revealed that TRAF3 and TRAF5 can play diverse roles for different receptors even in the same cell type, as well as distinct roles in different cell types. Evidence indicates that TRAF3 and TRAF5 play important roles beyond the TNFR-superfamily (SF) and viral mimics of its members, mediating certain innate immune receptor and cytokine receptor signals, and most recently, signals delivered by the T-cell receptor (TCR) signaling complex. Additionally, much research has demonstrated the importance of TRAF3-mediated cellular regulation via its cytoplasmic interactions with additional signaling proteins. In particular, we discuss below evidence for the participation by TRAF3 in a number of the regulatory post-translational modifications involving ubiquitin that are important in various signaling pathways.

Tumor Necrosis Factor-alpha - metabolism

Humans

Protein Processing, Post-Translational - genetics

Tumor Necrosis Factor-alpha - genetics

NF-kappa B - immunology

Ubiquitin - metabolism

Cell Survival - genetics

TNF Receptor-Associated Factor 5 - immunology

NF-kappa B - metabolism

Signal Transduction - immunology

T-Lymphocytes - metabolism

Myeloid Cells - immunology

TNF Receptor-Associated Factor 3 - genetics

Gene Expression - immunology

Tumor Necrosis Factor-alpha - immunology

Protein Processing, Post-Translational - immunology

B-Lymphocytes - metabolism

Receptors, Tumor Necrosis Factor - genetics

Receptors, Tumor Necrosis Factor - metabolism

TNF Receptor-Associated Factor 3 - metabolism

Signal Transduction - genetics

Ubiquitin - genetics

TNF Receptor-Associated Factor 5 - metabolism

Cell Survival - immunology

Immunity, Innate

Mice, Knockout

TNF Receptor-Associated Factor 5 - genetics

Animals

B-Lymphocytes - immunology

NF-kappa B - genetics

TNF Receptor-Associated Factor 3 - immunology

Myeloid Cells - metabolism

Protein Binding

T-Lymphocytes - immunology

Mice

Receptors, Tumor Necrosis Factor - immunology

Ubiquitin - immunology

Details

Title: Subtitle: Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions
Creators: Joanne M Hildebrand - Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
Zuoan Yi
Claire M Buchta
Jayakumar Poovassery
Laura L Stunz
Gail A Bishop
Resource Type: Journal article
Publication Details: Immunological reviews, Vol.244(1), pp.55-74
DOI: 10.1111/j.1600-065X.2011.01055.x
PMID: 22017431
PMCID: PMC3202299
NLM abbreviation: Immunol Rev
ISSN: 0105-2896
eISSN: 1600-065X
Publisher: England
Grant note: R01 AI028847 / NIAID NIH HHS R01 AI049993 / NIAID NIH HHS R01 CA099997-09 / NCI NIH HHS R56 AI049993 / NIAID NIH HHS AI49993 / NIAID NIH HHS R01 AI049993-09 / NIAID NIH HHS AI28847 / NIAID NIH HHS T32 AI007485-18 / NIAID NIH HHS T32 AI007485 / NIAID NIH HHS R01 AI028847-20 / NIAID NIH HHS CA099997 / NCI NIH HHS R01 CA099997 / NCI NIH HHS R56 AI028847 / NIAID NIH HHS
Language: English
Date published: 11/2011
Academic Unit: Microbiology and Immunology; President
Record Identifier: 9984001200702771

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