Rolipram treatment during consolidation ameliorates long-term object location memory in aged male mice

Mathieu E Wimmer; Jennifer M Blackwell; Ted Abel

doi:10.1016/j.nlm.2020.107168

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Rolipram treatment during consolidation ameliorates long-term object location memory in aged male mice

Journal article

Peer reviewed

Rolipram treatment during consolidation ameliorates long-term object location memory in aged male mice

Mathieu E Wimmer, Jennifer M Blackwell and Ted Abel

Neurobiology of learning and memory, Vol.169, pp.107168-107168

03/2020

DOI: 10.1016/j.nlm.2020.107168

PMCID: PMC7106430

PMID: 31962134

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https://www.ncbi.nlm.nih.gov/pmc/articles/7106430View

Open Access

Abstract

Normal aging is accompanied by cognitive and memory impairments that negatively impact quality of life for the growing elderly population. Hippocampal function is most vulnerable to the deleterious effects of aging, and deficits in hippocampus-dependent memories are common amongst aged individuals. Moreover, signaling networks such as the cAMP/PKA/CREB pathway, which are critical for memory consolidation, are dampened in healthy aged subjects. Phosphodiesterase (PDE) enzymes that break down cAMP are also affected by aging, and increased break down of cAMP by PDEs may contribute to reduced activity of the cAMP/PKA/CREB signaling network in the brain of aged individuals. Here, we report that the PDE4 inhibitor rolipram administered during consolidation of hippocampus-dependent object location memory improves aged-related spatial memory deficits in aged mice.

Animals

Aging - physiology

Memory Consolidation - drug effects

Phosphodiesterase 4 Inhibitors - administration & dosage

Mice, Inbred C57BL

Memory, Long-Term - drug effects

Aging - psychology

Male

Memory, Long-Term - physiology

Rolipram - administration & dosage

Memory Consolidation - physiology

Details

Title: Subtitle: Rolipram treatment during consolidation ameliorates long-term object location memory in aged male mice
Creators: Mathieu E Wimmer - Department of Psychology and Program in Neuroscience, Temple University, Philadelphia, PA 19122, USA
Jennifer M Blackwell - Neuroscience Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
Ted Abel - Department of Molecular Physiology and Biophysics, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242, USA. Electronic address: ted-abel@uiowa.edu
Resource Type: Journal article
Publication Details: Neurobiology of learning and memory, Vol.169, pp.107168-107168
DOI: 10.1016/j.nlm.2020.107168
PMID: 31962134
PMCID: PMC7106430
NLM abbreviation: Neurobiol Learn Mem
ISSN: 1074-7427
eISSN: 1095-9564
Publisher: United States
Grant note: P01 AG017628 / NIA NIH HHS T32 HL007953 / NHLBI NIH HHS R01 AG062398 / NIA NIH HHS
Language: English
Date published: 03/2020
Academic Unit: Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
Record Identifier: 9984070340402771

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