Journal article
Rostral anterior cingulate cortex is a structural correlate of repetitive TMS treatment response in depression
Brain stimulation, Vol.11(3), pp.575-581
05/2018
DOI: 10.1016/j.brs.2018.01.029
PMCID: PMC6136654
PMID: 29454551
Abstract
Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for medication-refractory major depression, yet the mechanisms of action for this intervention are poorly understood. Here we investigate cerebral cortex thickness as a possible biomarker of rTMS treatment response.
Longitudinal change in cortical thickness is evaluated relative to clinical outcomes across 48 participants in 2 cohorts undergoing left dorsolateral prefrontal cortex rTMS as a treatment for depression.
Our results reveal changes in thickness in a region of the left rostral anterior cingulate cortex that correlate with clinical response, with this region becoming thicker in patients who respond favorably to rTMS and thinner in patients with a less favorable response. Moreover, the baseline cortical thickness in this region correlates with rTMS treatment response – those patients with thinner cortex before treatment tended to have the most clinical improvement.
This study is the first analysis of longitudinal cortical thickness change with rTMS as a treatment for depression with similar results across two cohorts. These results support further investigation into the use of structural MRI as a possible biomarker of rTMS treatment response.
•Does cortical thickness change in response to rTMS treatment of depression?•We show clinical improvement correlates with change in cerebral cortex thickness.•This is specific to the rostral anterior cingulate cortex. Moreover, pre-treatment cortical thickness in this region also correlates with eventual response.
Details
- Title: Subtitle
- Rostral anterior cingulate cortex is a structural correlate of repetitive TMS treatment response in depression
- Creators
- Aaron D Boes - Neuroimaging & Noninvasive Brain Stimulation Laboratory, Departments of Pediatrics, Neurology & Psychiatry, W 278 General Hospital, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USABrandt D Uitermarkt - Neuroimaging & Noninvasive Brain Stimulation Laboratory, Departments of Pediatrics, Neurology & Psychiatry, W 278 General Hospital, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAFatimah M Albazron - Neuroimaging & Noninvasive Brain Stimulation Laboratory, Departments of Pediatrics, Neurology & Psychiatry, W 278 General Hospital, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAMartin J Lan - Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Dr., Unit 42, New York, NY 10032, USAConor Liston - Department of Psychiatry, Weill Cornell Medical College, 525 East 68th St, New York, NY 10065, USAAlvaro Pascual-Leone - Berenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USAMarc J Dubin - Department of Psychiatry, Weill Cornell Medical College, 525 East 68th St, New York, NY 10065, USAMichael D Fox - Berenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
- Resource Type
- Journal article
- Publication Details
- Brain stimulation, Vol.11(3), pp.575-581
- DOI
- 10.1016/j.brs.2018.01.029
- PMID
- 29454551
- PMCID
- PMC6136654
- NLM abbreviation
- Brain Stimul
- ISSN
- 1935-861X
- eISSN
- 1876-4754
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: K12HD027748-24, K12NS098482; DOI: 10.13039/100001479, name: Sidney R. Baer, Jr. Foundation; DOI: 10.13039/100001024, name: Roy J. Carver Trust; DOI: 10.13039/100000002, name: National Institutes of Health, award: K23NS083741, R01 MH113929; DOI: 10.13039/100007429, name: Nancy Lurie Marks Foundation; name: Mather’s Foundation, award: 29943; DOI: 10.13039/100001479, name: Sidney R. Baer Jr. Foundation; DOI: 10.13039/100000002, name: National Institutes of Health, award: R01 MH100186, R01 HD069776, R01 NS073601, R21 MH099196, R21 NS085491, R21 HD07616; name: National Centres of Competence in Research; DOI: 10.13039/100000002, name: National Center for Advancing Translation Sciences, National Institutes of Health, award: UL1 RR025758
- Language
- English
- Date published
- 05/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984070420202771
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