Journal article
Rotating-shield brachytherapy for cervical cancer
Physics in medicine & biology, Vol.58(11), pp.3931-3941
05/16/2013
DOI: 10.1088/0031-9155/58/11/3931
PMID: 23680601
Abstract
In this treatment planning study, the potential benefits of a rotating shield brachytherapy (RSBT) technique based on a partially-shielded electronic brachytherapy source were assessed for treating cervical cancer. Conventional intracavitary brachytherapy (ICBT), intracavitary plus supplementary interstitial (IS+ICBT), and RSBT treatment plans for azimuthal emission angles of 180° (RSBT-180) and 45° (RSBT-45) were generated for five patients. For each patient, high-risk clinical target volume (HR-CTV) equivalent dose in 2 Gy fractions (EQD2) (α β = 10 Gy) was escalated until bladder, rectum, or sigmoid colon tolerance EQD2 values were reached. External beam radiotherapy dose (1.8 Gy × 25) was accounted for, and brachytherapy was assumed to have been delivered in 5 fractions. IS+ICBT provided a greater HR-CTV D90 (minimum EQD2 to the hottest 90%) than ICBT. D90 was greater for RSBT-45 than IS+ICBT for all five patients, and greater for RSBT-180 than IS+ICBT for two patients. When the RSBT-45 180 plan with the lowest HR-CTV D90 that was greater than the D90 the ICBT or IS+ICBT plan was selected, the average (range) of D90 increases for RSBT over ICBT and IS+ICBT were 16.2 (6.3-27.2)and 8.5 (0.03-20.16) Gy, respectively. The average (range) treatment time increase per fraction of RSBT was 34.56 (3.68-70.41) min over ICBT and 34.59 (3.57-70.13) min over IS+ICBT. RSBT can increase D90 over ICBT and IS+ICBT without compromising organ-at-risk sparing. The D90 and treatment time improvements from RSBT depend on the patient and shield emission angle.
Details
- Title: Subtitle
- Rotating-shield brachytherapy for cervical cancer
- Creators
- Wenjun Yang - University of Iowa Department of Biomedical Engineering, 1402 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA 52242, USAYusung Kim - University of Iowa Department of Radiation Oncology, 200 Hawkins Drive, Iowa City, IA 52242, USAXiaodong Wu - University of Iowa Department of Electrical and Computer Engineering, 4016 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA 52242, USAQi Song - University of Iowa Department of Electrical and Computer Engineering, 4016 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA 52242, USAYunlong Liu - University of Iowa Department of Electrical and Computer Engineering, 4016 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA 52242, USASudershan K Bhatia - University of Iowa Department of Radiation Oncology, 200 Hawkins Drive, Iowa City, IA 52242, USAWenqing Sun - University of Iowa Department of Radiation Oncology, 200 Hawkins Drive, Iowa City, IA 52242, USARyan T Flynn - University of Iowa Department of Radiation Oncology, 200 Hawkins Drive, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Physics in medicine & biology, Vol.58(11), pp.3931-3941
- Publisher
- IOP Publishing
- DOI
- 10.1088/0031-9155/58/11/3931
- PMID
- 23680601
- ISSN
- 0031-9155
- eISSN
- 1361-6560
- Language
- English
- Date published
- 05/16/2013
- Academic Unit
- Electrical and Computer Engineering; Radiation Oncology
- Record Identifier
- 9984047876102771
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