Journal article
Rubella Virus Infected Macrophages and Neutrophils Define Patterns of Granulomatous Inflammation in Inborn and Acquired Errors of Immunity
Frontiers in immunology, Vol.12, pp.796065-796065
12/20/2021
DOI: 10.3389/fimmu.2021.796065
PMCID: PMC8728873
PMID: 35003119
Abstract
Rubella virus (RuV) has recently been found in association with granulomatous inflammation of the skin and several internal organs in patients with inborn errors of immunity (IEI). The cellular tropism and molecular mechanisms of RuV persistence and pathogenesis in select immunocompromised hosts are not clear. We provide clinical, immunological, virological, and histological data on a cohort of 28 patients with a broad spectrum of IEI and RuV-associated granulomas in skin and nine extracutaneous tissues to further delineate this relationship. Combined immunodeficiency was the most frequent diagnosis (67.8%) among patients. Patients with previously undocumented conditions, i.e., humoral immunodeficiencies, a secondary immunodeficiency, and a defect of innate immunity were identified as being susceptible to RuV-associated granulomas. Hematopoietic cell transplantation was the most successful treatment in this case series resulting in granuloma resolution; steroids, and TNF-α and IL-1R inhibitors were moderately effective. In addition to M2 macrophages, neutrophils were identified by immunohistochemical analysis as a novel cell type infected with RuV. Four patterns of RuV-associated granulomatous inflammation were classified based on the structural organization of granulomas and identity and location of cell types harboring RuV antigen. Identification of conditions that increase susceptibility to RuV-associated granulomas combined with structural characterization of the granulomas may lead to a better understanding of the pathogenesis of RuV-associated granulomas and discover new targets for therapeutic interventions.
Details
- Title: Subtitle
- Rubella Virus Infected Macrophages and Neutrophils Define Patterns of Granulomatous Inflammation in Inborn and Acquired Errors of Immunity
- Creators
- Ludmila Perelygina - Centers for Disease Control and PreventionRaeesa Faisthalab - Centers for Disease Control and PreventionEmily Abernathy - Centers for Disease Control and PreventionMin-Hsin Chen - Centers for Disease Control and Prevention, Division of Viral Diseases, Atlanta, GA, United StatesLiJuan Hao - Centers for Disease Control and PreventionLionel Bercovitch - Brown UniversityDiana K Bayer - University of IowaLenora M Noroski - Texas Children's HospitalMichael T Lam - Texas Children's HospitalMaria Pia Cicalese - The San Raffaele Telethon Institute for Gene TherapyWaleed Al-Herz - Al-Sabah HospitalArti Nanda - Al-Sabah HospitalJoud Hajjar - Texas Children's HospitalKoen Vanden Driessche - Department of Pediatrics, Queen Mathilde Mother and Child Centre, Antwerp University Hospital, Antwerp, BelgiumShari Schroven - Antwerp University HospitalJulie Leysen - Antwerp University HospitalMisha Rosenbach - University of PennsylvaniaPhilipp Peters - Ludwig-Maximilians-Universität MünchenJohannes Raedler - Ludwig-Maximilians-Universität MünchenMichael H Albert - Ludwig-Maximilians-Universität MünchenRoshini S Abraham - Nationwide Children's HospitalHemalatha G Rangarjan - Nationwide Children's HospitalDavid Buchbinder - Children's Hospital of Orange CountyLisa Kobrynski - Emory UniversityAnne Pham-Huy - Children's Hospital of Eastern OntarioJulie Dhossche - Oregon Health & Science UniversityCharlotte Cunningham Rundles - Icahn School of Medicine at Mount SinaiAnna K Meyer - National Jewish HealthAmy Theos - University of Alabama at BirminghamT Prescott Atkinson - University of Alabama at BirminghamAmy Musiek - Washington University in St. LouisMehdi Adeli - Hamad Medical CorporationUte Derichs - Johannes Gutenberg University MainzChristoph Walz - Ludwig-Maximilians-Universität MünchenRenate Krüger - Charité - Universitätsmedizin BerlinHorst von Bernuth - Berlin Institute of Health at Charité - Universitätsmedizin BerlinChristoph Klein - Ludwig-Maximilians-Universität MünchenJoseph Icenogle - Centers for Disease Control and PreventionFabian Hauck - Ludwig-Maximilians-Universität MünchenKathleen E Sullivan - Children's Hospital of Philadelphia
- Resource Type
- Journal article
- Publication Details
- Frontiers in immunology, Vol.12, pp.796065-796065
- DOI
- 10.3389/fimmu.2021.796065
- PMID
- 35003119
- PMCID
- PMC8728873
- ISSN
- 1664-3224
- eISSN
- 1664-3224
- Grant note
- R21 AI130967 / NIAID NIH HHS R01 AI141877 / NIAID NIH HHS
- Language
- English
- Date published
- 12/20/2021
- Academic Unit
- Stead Family Department of Pediatrics; Rheumatology, Allergy, and Immunology; Internal Medicine
- Record Identifier
- 9984695829402771
Metrics
6 Record Views