Journal article
Ryanodine receptor of skeletal muscle is a gap junction-type channel
Science (American Association for the Advancement of Science), Vol.242(4875), pp.99-102
1988
DOI: 10.1126/science.2459777
PMID: 2459777
Abstract
In the sarcoplasmic reticulum membrane of skeletal muscle, the ryanodine receptor forms an aqueous pore identified as the calcium-release pathway that operates during excitation-contraction coupling. The purified ryanodine receptor channel has now been shown to have four properties usually associated with gap junction channels: (i) a large nonspecific voltage-dependent conductance consisting of several open states; (ii) an inhibition of open probability by low pH; (iii) an inhibition of open probability by calcium; and (iv) a sensitivity to blockade by heptanol and octanol but not other alcohols. This functional homology may provide an insight into the mechanism of how muscle cells transduce depolarization into an intracellular release of calcium.
Details
- Title: Subtitle
- Ryanodine receptor of skeletal muscle is a gap junction-type channel
- Creators
- Jianjie Ma - Baylor coll. medicine, Houston TX 77030, United StatesM FILL - Baylor coll. medicine, Houston TX 77030, United StatesC. M KNUDSON - Baylor coll. medicine, Houston TX 77030, United StatesK. P CAMPBELL - Baylor coll. medicine, Houston TX 77030, United StatesR CORONADO - Baylor coll. medicine, Houston TX 77030, United States
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.242(4875), pp.99-102
- Publisher
- American Association for the Advancement of Science; Washington, DC
- DOI
- 10.1126/science.2459777
- PMID
- 2459777
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 1988
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pathology; Iowa Neuroscience Institute; Radiation Oncology
- Record Identifier
- 9984047978502771
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