Journal article
S-nitrosocysteine elicits hemodynamic responses similar to those of the Bezold–Jarisch reflex via activation of stereoselective recognition sites
European journal of pharmacology, Vol.531(1), pp.254-258
02/15/2006
DOI: 10.1016/j.ejphar.2005.11.027
PMID: 16438953
Abstract
We report here that l-S-nitrosocysteine elicits rapid dose-dependent reductions in mean arterial blood pressure, heart rate, cardiac output and renal sympathetic nerve activity in conscious rats whereas d-S-nitrosocysteine elicits minor responses. The reductions in mean arterial blood pressure, heart rate and cardiac output elicited by l- and d-S-nitrosocysteine were markedly diminished after blockade of cardiac muscarinic cholinergic receptors whereas the reductions in renal sympathetic nerve activity were not affected. The Bezold–Jarisch reflex-like pattern of responses elicited by the stereoisomers, suggests that (i) l- and l-S-nitrosocysteine may activate stereoselective recognition sites on vagal cardiopulmonary afferents, which elicit hemodynamic responses via increases in cardiovagal efferent nerve activity and decreases in sympathetic nerve activity, and (ii) l-S-nitrosocysteine is a more potent agonist of these recognition sites than is d-S-nitrosocysteine.
Details
- Title: Subtitle
- S-nitrosocysteine elicits hemodynamic responses similar to those of the Bezold–Jarisch reflex via activation of stereoselective recognition sites
- Creators
- Stephen J. Lewis - Case Western Reserve UniversityJoy R. Owen - University of GeorgiaJames N. Bates - University of Iowa, Anesthesia
- Resource Type
- Journal article
- Publication Details
- European journal of pharmacology, Vol.531(1), pp.254-258
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.ejphar.2005.11.027
- PMID
- 16438953
- ISSN
- 0014-2999
- eISSN
- 1879-0712
- Language
- English
- Date published
- 02/15/2006
- Academic Unit
- Anesthesia
- Record Identifier
- 9984424843702771
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