S100A12 as a marker of worse cardiac output and mortality in pulmonary hypertension

Argyrios Tzouvelekis; Jose D Herazo-Maya; Changwan Ryu; Jen-Hwa Chu; Yingze Zhang; Kevin F Gibson; Percy K Adonteng-Boateng; Qin Li; Hongyi Pan; Benjamin Cherry; Ferhaan Ahmad; Hubert J Ford; Erica L Herzog; Naftali Kaminski; Wassim H Fares

doi:10.1111/resp.13302

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S100A12 as a marker of worse cardiac output and mortality in pulmonary hypertension

Journal article

Open access

Peer reviewed

S100A12 as a marker of worse cardiac output and mortality in pulmonary hypertension

Argyrios Tzouvelekis, Jose D Herazo-Maya, Changwan Ryu, Jen-Hwa Chu, Yingze Zhang, Kevin F Gibson, Percy K Adonteng-Boateng, Qin Li, Hongyi Pan, Benjamin Cherry, …

Respirology (Carlton, Vic.), Vol.23(8), pp.771-779

08/2018

DOI: 10.1111/resp.13302

PMCID: PMC6047907

PMID: 29611244

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Abstract

Molecular biomarkers are needed to refine prognostication and phenotyping of pulmonary hypertension (PH) patients. S100A12 is an emerging biomarker of various inflammatory diseases. This study aims to determine the prognostic value of S100A12 in PH. Exploratory microarray analysis performed on peripheral blood mononuclear cells (PBMC) collected from idiopathic pulmonary fibrosis (IPF) patients suggested an association between S100A12 and both PH and mortality. So the current study was designed to evaluate for an association between S100A12 in peripheral blood collected from two well-phenotyped PH cohorts in two other centres to derive and validate an association between S100A12 protein serum concentrations and mortality. The majority of the patients in the discovery and validation cohorts were either World Health Organization (WHO) group 1 (pulmonary arterial hypertension (PAH)) or 3 (lung disease-associated) PH. In the discovery PH cohort, S100A12 was significantly increased in patients with PH (n = 51) compared to controls (n = 22) (29.8 vs 15.7 ng/mL, P < 0.001) and negatively correlated with cardiac output (r = -0.58, P < 0.001) in PH patients. When S100A12 data were pooled from both cohorts, PAH and non-PAH PH patients had higher S100A12 compared to healthy external controls (32.6, 30.9, 15.7 ng/mL; P < 0.001). S100A12 was associated with an increased risk in overall mortality in PH patients in both the discovery (n = 51; P = 0.008) and validation (n = 40; P < 0.001) cohorts. S100A12 levels are increased in PH patients and are associated with increased mortality.

Adult

Aged

Biomarkers - blood

Cardiac Output

Case-Control Studies

Cohort Studies

Female

Humans

Hypertension, Pulmonary - blood

Hypertension, Pulmonary - mortality

Hypertension, Pulmonary - physiopathology

Leukocytes, Mononuclear

Lung - physiopathology

Male

Middle Aged

Prognosis

S100A12 Protein - blood

Details

Title: Subtitle: S100A12 as a marker of worse cardiac output and mortality in pulmonary hypertension
Creators: Argyrios Tzouvelekis - Yale University
Jose D Herazo-Maya - Yale University
Changwan Ryu - Yale University
Jen-Hwa Chu - Yale University
Yingze Zhang - University of Pittsburgh
Kevin F Gibson - University of Pittsburgh
Percy K Adonteng-Boateng - Yale University
Qin Li - Yale University
Hongyi Pan - Yale University
Benjamin Cherry - Yale University
Ferhaan Ahmad - University of Iowa
Hubert J Ford - University of North Carolina at Chapel Hill
Erica L Herzog - Yale University
Naftali Kaminski - Yale University
Wassim H Fares - Yale University
Resource Type: Journal article
Publication Details: Respirology (Carlton, Vic.), Vol.23(8), pp.771-779
DOI: 10.1111/resp.13302
PMID: 29611244
PMCID: PMC6047907
NLM abbreviation: Respirology
ISSN: 1323-7799
eISSN: 1440-1843
Grant note: R00 HL114651 / NHLBI NIH HHS R01 HL127349 / NHLBI NIH HHS U01 HL108642 / NHLBI NIH HHS R01 HL109233 / NHLBI NIH HHS UL1 RR024153 / NCRR NIH HHS R03 HL095401 / NHLBI NIH HHS UL1 TR001863 / NCATS NIH HHS
Language: English
Date published: 08/2018
Academic Unit: Radiology; Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984297493702771

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