Journal article
S100A12 in Digestive Diseases and Health: A Scoping Review
Gastroenterology research and practice, Vol.2020, pp.2868373-11
2020
DOI: 10.1155/2020/2868373
PMCID: PMC7061133
PMID: 32184815
Abstract
Calgranulin proteins are an important class of molecules involved in innate immunity. These members of the S100 class of the EF-hand family of calcium-binding proteins have numerous cellular and antimicrobial functions. One protein in particular, S100A12 (also called EN-RAGE or calgranulin C), is highly abundant in neutrophils during acute inflammation and has been implicated in immune regulation. Structure-function analyses reveal that S100A12 has the capacity to bind calcium, zinc, and copper, processes that contribute to nutritional immunity against invading microbial pathogens. S100A12 is a ligand for the receptor for advanced glycation end products (RAGE), toll-like receptor 4 (TLR4), and CD36, which promote cellular and immunological pathways to alter inflammation. We conducted a scoping review of the existing literature to define what is known about the association of S100A12 with digestive disease and health. Results suggest that S100A12 is implicated in gastroenteritis, necrotizing enterocolitis, gastritis, gastric cancer, Crohn's disease, irritable bowel syndrome, inflammatory bowel disease, and digestive tract cancers. Together, these results reveal S100A12 is an important molecule broadly associated with the pathogenesis of digestive diseases.
Details
- Title: Subtitle
- S100A12 in Digestive Diseases and Health: A Scoping Review
- Creators
- Alexandre Carvalho - Trinity Health Ann Arbor HospitalJacky Lu - Vanderbilt UniversityJamisha D. Francis - Vanderbilt UniversityRebecca E. Moore - Vanderbilt UniversityKathryn P. Haley - Grand Valley State UniversityRyan S. Doster - Vanderbilt UniversitySteven D. Townsend - Vanderbilt UniversityJeremiah G. Johnson - University of Tennessee at KnoxvilleSteven M. Damo - Fisk UniversityJennifer A. Gaddy - Vanderbilt University
- Resource Type
- Journal article
- Publication Details
- Gastroenterology research and practice, Vol.2020, pp.2868373-11
- Publisher
- Hindawi Publishing Group
- DOI
- 10.1155/2020/2868373
- PMID
- 32184815
- PMCID
- PMC7061133
- ISSN
- 1687-6121
- eISSN
- 1687-630X
- Number of pages
- 11
- Grant note
- R01 HD090061; 2T32HL007411-36; GM05551 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA IK2BX001701 / Office of Medical Research, Department of Veterans Affairs; US Department of Veterans Affairs Vanderbilt University Medical Center's Digestive Disease Research Center UL1 RR024975-01 / National Center for Research Resources; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) NOVAD 2 UL1 TR000445-06 / National Center for Advancing Translational Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) NSF 1547757; NSF 1400969; NSF CHE-1847804 / National Science Foundation; National Science Foundation (NSF) Vanderbilt Faculty Research Scholars Award P30DK058404 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 2020
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984696724502771
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