Journal article
SAMHD1 Suppression of Antiviral Immune Responses
Trends in microbiology (Regular ed.), Vol.27(3), pp.254-267
03/2019
DOI: 10.1016/j.tim.2018.09.009
PMCID: PMC6377309
PMID: 30336972
Abstract
SAMHD1 is a host triphosphohydrolase that degrades intracellular deoxynucleoside triphosphates (dNTPs) to a lower level that restricts viral DNA synthesis, and thus prevents replication of diverse viruses in nondividing cells. Recent progress indicates that SAMHD1 negatively regulates antiviral innate immune responses and inflammation through interacting with various key proteins in immune signaling and DNA damage-repair pathways. SAMHD1 can also modulate antibody production in adaptive immune responses. In this review, we summarize how SAMHD1 regulates antiviral immune responses through distinct mechanisms, and discuss the implications of these new functions of SAMHD1. Furthermore, we propose important new questions and future directions that can advance functional and mechanistic studies of SAMHD1-mediated immune regulation during viral infections.
Details
- Title: Subtitle
- SAMHD1 Suppression of Antiviral Immune Responses
- Creators
- Shuliang Chen - School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, PR China; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USASerena Bonifati - Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USAZhihua Qin - Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USACorine St Gelais - Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USALi Wu - Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA. Electronic address: wu.840@osu.edu
- Resource Type
- Journal article
- Publication Details
- Trends in microbiology (Regular ed.), Vol.27(3), pp.254-267
- DOI
- 10.1016/j.tim.2018.09.009
- PMID
- 30336972
- PMCID
- PMC6377309
- NLM abbreviation
- Trends Microbiol
- ISSN
- 0966-842X
- eISSN
- 1878-4380
- Publisher
- England
- Grant note
- R01 AI104483 / NIAID NIH HHS R01 GM128212 / NIGMS NIH HHS R01 AI120209 / NIAID NIH HHS
- Language
- English
- Date published
- 03/2019
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984002383302771
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