Journal article
SAMHD1: a new contributor to HIV-1 restriction in resting CD4+ T-cells
Retrovirology, Vol.9(1), pp.88-88
10/23/2012
DOI: 10.1186/1742-4690-9-88
PMCID: PMC3492151
PMID: 23092163
Abstract
Resting CD4+ T-cells are critical for establishing HIV-1 reservoirs. It has been known for over two decades that resting CD4+ T-cells are refractory to HIV-1 infection, but the underlying mechanisms are not fully understood. Compared with activated CD4+ T-cells that support HIV-1 infection, resting CD4+ T-cells have lower levels of dNTPs, which limit HIV-1 reverse transcription. The dNTPase SAMHD1 has been identified as an HIV-1 restriction factor in non-cycling myeloid cells. Two recent studies revealed that SAMHD1 restricts HIV-1 infection in resting CD4+ T-cells, suggesting a common mechanism of HIV-1 restriction in non-cycling cells that may contribute to viral immunopathogenesis.
Details
- Title: Subtitle
- SAMHD1: a new contributor to HIV-1 restriction in resting CD4+ T-cells
- Creators
- Li Wu - Center for Retrovirus Research, Department of Veterinary Bioscience, The Ohio State University, 1900 Coffey Road, Columbus, OH 43210, USA. wu.840@osu.edu
- Resource Type
- Journal article
- Publication Details
- Retrovirology, Vol.9(1), pp.88-88
- DOI
- 10.1186/1742-4690-9-88
- PMID
- 23092163
- PMCID
- PMC3492151
- NLM abbreviation
- Retrovirology
- ISSN
- 1742-4690
- eISSN
- 1742-4690
- Publisher
- England
- Grant note
- R21 AI102822 / NIAID NIH HHS AI102822 / NIAID NIH HHS R21 AI098524 / NIAID NIH HHS AI098524 / NIAID NIH HHS
- Language
- English
- Date published
- 10/23/2012
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984001119402771
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