Journal article
SAMHD1: a new insight into HIV-1 restriction in myeloid cells
Retrovirology, Vol.8(1), pp.55-55
07/08/2011
DOI: 10.1186/1742-4690-8-55
PMCID: PMC3142215
PMID: 21740548
Abstract
Human myeloid-lineage cells are refractory to HIV-1 infection. The Vpx proteins from HIV-2 and sooty mangabey SIV render these cells permissive to HIV-1 infection through proteasomal degradation of a putative restriction factor. Two recent studies discovered the cellular protein SAMHD1 to be this restriction factor, demonstrating that Vpx induces proteasomal degradation of SAMHD1 and enhances HIV-1 infection in myeloid-lineage cells. SAMHD1 functions as a myeloid-cell-specific HIV-1 restriction factor by inhibiting viral DNA synthesis. Here we discuss the implications of these findings in delineating the mechanisms of HIV-1 restriction in myeloid-lineage cells and the potential role of Vpx in lentiviral pathogenesis.
Details
- Title: Subtitle
- SAMHD1: a new insight into HIV-1 restriction in myeloid cells
- Creators
- Corine St Gelais - Center for Retrovirus Research, Department of Veterinary Bioscience, The Ohio State University, 1900 Coffey Road, Columbus, OH 43210, USALi Wu - Center for Retrovirus Research, Department of Veterinary Bioscience, The Ohio State University, 1900 Coffey Road, Columbus, OH 43210, USA
- Resource Type
- Journal article
- Publication Details
- Retrovirology, Vol.8(1), pp.55-55
- DOI
- 10.1186/1742-4690-8-55
- PMID
- 21740548
- PMCID
- PMC3142215
- NLM abbreviation
- Retrovirology
- ISSN
- 1742-4690
- eISSN
- 1742-4690
- Publisher
- BioMed Central
- Language
- English
- Date published
- 07/08/2011
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984001127002771
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