Journal article
SARS-CoV-2 Infection during Pregnancy in a Rural Midwest All-delivery Cohort and Associated Maternal and Neonatal Outcomes
American journal of perinatology, Vol.38(6), pp.614-621
05/2021
DOI: 10.1055/s-0041-1723938
PMID: 33611783
Abstract
This study aimed to estimate the prevalence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) among pregnant patients at the time of delivery in a rural Midwest tertiary care hospital and to examine demographics, clinical factors, and maternal and neonatal outcomes associated with SARS-CoV-2 infection during pregnancy.
This prospective cohort study included all delivering patients between May 1 and September 22, 2020 at the University of Iowa Hospitals and Clinics. Plasma SARS-CoV-2 antibody testing was performed. SARS-CoV-2 viral reverse-transcription polymerase chain reaction (RT-PCR) results and maternal and neonatal outcomes were collected from the electronic medical record. Data were analyzed using univariate statistical methods with clustering for multiple births.
In total, 1,000 patients delivered between May 1 and September 22, 2020. Fifty-eight (5.8%) were SARS-CoV-2 antibody positive. Twenty-three also tested viral positive during pregnancy. Three of 1,000 (0.3%) were viral positive on admission but antibody negative. The median age was 30 years (interquartile range [IQR]: 26-33 years) and body mass index was 31.75 kg/m
(IQR 27.7-37.5 kg/m
). The cesarean delivery rate was 34.0%. The study population was primarily white (71.6%); however, 41.0% of SARS-CoV-2 infected patients identified as Black, 18.0% as Hispanic/Latino, 3.3% as Native Hawaiian/Pacific Islander, and only 27.9% as White (
< 0.0001). SARS-CoV-2 infection was more likely in patients without private insurance (
= 0.0243). Adverse maternal and/or neonatal outcomes were not more likely in patients with evidence of infection during pregnancy. Two SARS-CoV-2 infected patients were admitted to the intensive care unit. There were no maternal deaths during the study period.
In this largely rural Midwest population, 6.1% of delivering patients had evidence of past or current SARS-CoV-2 infection. Rates of SARS-CoV-2 during pregnancy were higher among racial and ethnic minorities and patients without private insurance. The SARS-CoV-2 infected patients and their neonates were not found to be at increased risk for adverse outcomes.
· SARS-CoV-2 seroprevalence rate in pregnant population in Iowa is 5.8%.. · Infections are higher among minorities, non-English speakers, and patients without private insurance.. · No increased adverse maternal/neonatal outcomes observed for SARS-CoV-2 infected mothers..
Details
- Title: Subtitle
- SARS-CoV-2 Infection during Pregnancy in a Rural Midwest All-delivery Cohort and Associated Maternal and Neonatal Outcomes
- Creators
- Haley A Steffen - University of IowaSamantha R Swartz - University of IowaJ Brooks Jackson - University of IowaKimberly A Kenne - University of IowaPatrick P Ten Eyck - University of IowaAbbey S Merryman - University of IowaClaire N Castaneda - University of IowaKatharine Marsden - University of IowaTimothy Maxwell - University of IowaAnna E Merrill - University of IowaMatthew D Krasowski - University of IowaMary B Rysavy - University of Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of perinatology, Vol.38(6), pp.614-621
- DOI
- 10.1055/s-0041-1723938
- PMID
- 33611783
- NLM abbreviation
- Am J Perinatol
- ISSN
- 0735-1631
- eISSN
- 1098-8785
- Grant note
- UL1TR002537 / UL1TR002537
- Language
- English
- Date published
- 05/2021
- Academic Unit
- Pathology; Biostatistics; Family and Community Medicine; Obstetrics and Gynecology; Injury Prevention Research Center; VPMA - Administration
- Record Identifier
- 9984186576402771
Metrics
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