SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

Peter J Halfmann; Shun Iida; Kiyoko Iwatsuki-Horimoto; Tadashi Maemura; Maki Kiso; Suzanne M Scheaffer; Tamarand L Darling; Astha Joshi; Samantha Loeber; Gagandeep Singh; Stephanie L Foster; Baoling Ying; James Brett Case; Zhenlu Chong; Bradley Whitener; Juan Moliva; Katharine Floyd; Michiko Ujie; Noriko Nakajima; Mutsumi Ito; Ryan Wright; Ryuta Uraki; Prajakta Warang; Matthew Gagne; Rong Li; Yuko Sakai-Tagawa; Yanan Liu; Deanna Larson; Jorge E Osorio; Juan P Hernandez-Ortiz; Amy R Henry; Karl Ciouderis; Kelsey R Florek; Mit Patel; Abby Odle; Lok-Yin Roy Wong; Allen C Bateman; Zhongde Wang; Venkata-Viswanadh Edara; John Franks; Trushar Jeevan; Thomas Fabrizio; Jennifer DeBeauchamp; Lisa Kercher; Patrick Seiler; Ana Silvia Gonzalez-Reiche; Emilia Mia Sordillo; Lauren A Chang; Harm van Bakel; Viviana Simon; Daniel C Douek; Nancy J Sullivan; Larissa B Thackray; Hiroshi Ueki; Seiya Yamayoshi; Masaki Imai; Stanley Perlman; Richard J Webby; Robert A Seder; Mehul S Suthar; Adolfo García-Sastre; Michael Schotsaert; Tadaki Suzuki; Adrianus C M Boon; Michael S Diamond; Yoshihiro Kawaoka; Consortium Mount Sinai Pathogen Surveillance (PSP) study group

doi:10.1038/s41586-022-04441-6

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SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

Journal article

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SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

Peter J Halfmann, Shun Iida, Kiyoko Iwatsuki-Horimoto, Tadashi Maemura, Maki Kiso, Suzanne M Scheaffer, Tamarand L Darling, Astha Joshi, Samantha Loeber, Gagandeep Singh, …

Nature (London), Vol.603, pp.687-692

01/21/2022

DOI: 10.1038/s41586-022-04441-6

PMCID: PMC8942849

PMID: 35062015

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Abstract

The recent emergence of B.1.1.529, the Omicron variant has raised concerns for escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their activity in pre-clinical rodent models of respiratory tract disease. Here, using the collaborative network of the SARS-CoV-2 Assessment of Viral Evolution (SAVE) program of the National Institute of Allergy and Infectious Diseases (NIAID), we evaluated the ability of multiple B.1.1.529 Omicron isolates to cause infection and disease in immunocompetent and human ACE2 (hACE2) expressing mice and hamsters. Despite modeling data suggesting that B.1.1.529 spike can bind more avidly to murine ACE2 , we observed less infection in 129, C57BL/6, BALB/c, and K18-hACE2 transgenic mice as compared with previous SARS-CoV-2 variants, with limited weight loss and lower viral burden in the upper and lower respiratory tracts. In wild-type and hACE2 transgenic hamsters, lung infection, clinical disease, and pathology with B.1.1.529 also were milder compared to historical isolates or other SARS-CoV-2 variants of concern. Overall, experiments from the SAVE/NIAID network with several B.1.1.529 isolates demonstrate attenuated lung disease in rodents, which parallels preliminary human clinical data.

Details

Title: Subtitle: SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
Creators: Peter J Halfmann - Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA
Shun Iida - Department of Pathology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan
Kiyoko Iwatsuki-Horimoto - Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Tadashi Maemura - Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA
Maki Kiso - Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Suzanne M Scheaffer - Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
Tamarand L Darling - Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
Astha Joshi - Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
Samantha Loeber - Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA
Gagandeep Singh - Icahn School of Medicine at Mount Sinai
Stephanie L Foster - Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA
Baoling Ying - Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
James Brett Case - Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
Zhenlu Chong - Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
Bradley Whitener - Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
Juan Moliva - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Katharine Floyd - Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA
Michiko Ujie - Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Noriko Nakajima - Department of Pathology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan
Mutsumi Ito - Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Ryan Wright - Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA
Ryuta Uraki - The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan
Prajakta Warang - Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Matthew Gagne - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Rong Li - Department of Animal Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT, USA
Yuko Sakai-Tagawa - Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Yanan Liu - Department of Animal Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT, USA
Deanna Larson - Department of Animal Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT, USA
Jorge E Osorio - Colombia/Wisconsin One-Health Consortium and One-Health Genomic Laboratory, Universidad Nacional de Colombia, Medellín, Colombia
Juan P Hernandez-Ortiz - Colombia/Wisconsin One-Health Consortium and One-Health Genomic Laboratory, Universidad Nacional de Colombia, Medellín, Colombia
Amy R Henry - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Karl Ciouderis - Colombia/Wisconsin One-Health Consortium and One-Health Genomic Laboratory, Universidad Nacional de Colombia, Medellín, Colombia
Kelsey R Florek - Wisconsin State Laboratory of Hygiene, Madison, WI, USA
Mit Patel - Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA
Abby Odle - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA
Lok-Yin Roy Wong - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA
Allen C Bateman - Wisconsin State Laboratory of Hygiene, Madison, WI, USA
Zhongde Wang - Department of Animal Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT, USA
Venkata-Viswanadh Edara - Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA
John Franks - Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
Trushar Jeevan - Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
Thomas Fabrizio - Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
Jennifer DeBeauchamp - Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
Lisa Kercher - Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
Patrick Seiler - Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
Ana Silvia Gonzalez-Reiche - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Emilia Mia Sordillo - Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Lauren A Chang - Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Harm van Bakel - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Viviana Simon - Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Daniel C Douek - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Nancy J Sullivan - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Larissa B Thackray - Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
Hiroshi Ueki - The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan
Seiya Yamayoshi - The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan
Masaki Imai - The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan
Stanley Perlman - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA
Richard J Webby - Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
Robert A Seder - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Mehul S Suthar - Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA
Adolfo García-Sastre - The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Michael Schotsaert - Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Tadaki Suzuki - Department of Pathology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan
Adrianus C M Boon - Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA. jboon@wustl.edu
Michael S Diamond - The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu
Yoshihiro Kawaoka - The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan. yoshihiro.kawaoka@wisc.edu
Consortium Mount Sinai Pathogen Surveillance (PSP) study group
Resource Type: Journal article
Publication Details: Nature (London), Vol.603, pp.687-692
DOI: 10.1038/s41586-022-04441-6
PMID: 35062015
PMCID: PMC8942849
NLM abbreviation: Nature
eISSN: 1476-4687
Grant note: P51OD011132 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 75N93021C00017 / NIAID NIH HHS 75N93021C00014 / NIAID NIH HHS R01 AI129269 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) HHSN272201400008C / NIAID NIH HHS R01DK130425 / U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) 75N93020F00001/A38 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 75N93021C00016 / NIAID NIH HHS U01 AI151810 / NIAID NIH HHS R01 AI157155 / NIAID NIH HHS 75N93019C00051 / NIAID NIH HHS HHSN272201700041I / NIAID NIH HHS R56AI147623 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
Language: English
Date published: 01/21/2022
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9984211792802771

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