SARS-CoV-2 antibody changes in patients receiving COVID-19 convalescent plasma from normal and vaccinated donors

Judith Leon; Anna E Merrill; Kai Rogers; Julie Kurt; Spencer Dempewolf; Alexandra Ehlers; J. Brooks Jackson; C. Michael Knudson

doi:10.1016/j.transci.2021.103326

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SARS-CoV-2 antibody changes in patients receiving COVID-19 convalescent plasma from normal and vaccinated donors

Journal article

Open access

Peer reviewed

SARS-CoV-2 antibody changes in patients receiving COVID-19 convalescent plasma from normal and vaccinated donors

Judith Leon, Anna E Merrill, Kai Rogers, Julie Kurt, Spencer Dempewolf, Alexandra Ehlers, J. Brooks Jackson and C. Michael Knudson

Transfusion and apheresis science, Vol.61(2), 103326

11/2021

DOI: 10.1016/j.transci.2021.103326

PMCID: PMC8608660

PMID: 34862140

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Abstract

Vaccination has been shown to stimulate remarkably high antibody levels in donors who have recovered from COVID-19. Our objective was to measure patient antibody levels before and after transfusion with COVID-19 Convalescent Plasma (CCP) and compare the antibody levels following transfusion of CCP from vaccinated and nonvaccinated donors. Plasma samples before and after transfusion were obtained from 25 recipients of CCP and COVID-19 antibody levels measured. Factors that effect changes in antibody levels were examined. In the 21 patients who received CCP from nonvaccinated donors, modest increases in antibody levels were observed. Patients who received two units were more likely to seroconvert than those receiving just one unit. The strongest predictor of changes in patient antibody level was the CCP dose, calculated by the unit volume multiplied by the donor antibody level. Using patient plasma volume and donor antibody level, the post-transfusion antibody level could be predicted with reasonable accuracy(R 2 > 0.90). In contrast, the 4 patients who received CCP from vaccinated donors all had dramatic increases in antibody levels following transfusion of a single unit. In this subset of recipients, antibody levels observed after transfusion of CCP were comparable to those seen in donors who had fully recovered from COVID-19. If available, CCP from vaccinated donors with very high antibody levels should be used. One unit of CCP from vaccinated donors increases patient antibody levels much more than 1 or 2 units of CCP from unvaccinated donors.

COVID-19

COVID-19 convalescent plasma (CCP)

SARS-CoV-2

vaccinated donors

Details

Title: Subtitle: SARS-CoV-2 antibody changes in patients receiving COVID-19 convalescent plasma from normal and vaccinated donors
Creators: Judith Leon - University of Iowa Hospitals and Clinics
Anna E Merrill - University of Iowa Hospitals and Clinics
Kai Rogers - University of Iowa Hospitals and Clinics
Julie Kurt - University of Iowa Hospitals and Clinics
Spencer Dempewolf - University of Iowa Hospitals and Clinics
Alexandra Ehlers - University of Iowa Hospitals and Clinics
J. Brooks Jackson - University of Iowa Hospitals and Clinics
C. Michael Knudson - University of Iowa Hospitals and Clinics
Resource Type: Journal article
Publication Details: Transfusion and apheresis science, Vol.61(2), 103326
DOI: 10.1016/j.transci.2021.103326
PMID: 34862140
PMCID: PMC8608660
NLM abbreviation: Transfus Apher Sci
ISSN: 1473-0502
eISSN: 1878-1683
Publisher: Elsevier Ltd
Grant note: DOI: 10.13039/100008893, name: University of Iowa
Language: English
Date published: 11/2021
Academic Unit: Microbiology and Immunology; Pathology; Orthopedics and Rehabilitation; Radiation Oncology; Injury Prevention Research Center; VPMA - Administration
Record Identifier: 9984201117602771

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