Journal article
SARS-CoV-2 seropositivity among healthcare professionals in a rural state
Antimicrobial stewardship & healthcare epidemiology : ASHE, Vol.4(1), e190
10/01/2024
DOI: 10.1017/ash.2024.420
PMCID: PMC11505257
PMID: 39465214
Appears in UI Libraries Support Open Access
Abstract
Objectives:We evaluated SARS-CoV-2 anti-nucleocapsid (anti-N) seroconversion and seroreversion rates, risk factors associated with SARS-CoV-2 seroconversion, and COVID-19 risk perceptions among academic healthcare center employees in a rural state.Methods:Among employees aged ≥18 years who completed a screening survey (n = 1,377), we invited all respondents reporting previous COVID-19 (n = 85; 82 accepted) and a random selection of respondents not reporting previous COVID-19 (n = 370; 220 accepted) to participate. Participants completed surveys and provided blood samples at 3-month intervals (T0, T3, T6, T9). We used logistic regression to identify risk factors for seropositivity at T0.Results:The cohort was primarily direct patient caregivers (205/302; 67.9%), white (278/302; 92.1%), and female (212/302; 70.2%). At T0, 86/302 (28.4%) participants were seropositive. Of the seronegative participants, 6/198 (3.0%), 6/183 (3.3%), and 14/180 (7.8%) had seroconverted at T3, T6, and T9, respectively. The overall seroreversion rate was 6.98% at T9. At T0, nursing staff (odds ratio [OR], 2.37; 95% confidence interval [CI], 1.08, 5.19) and being within six feet of a non-household member outside of work (OR, 2.91; 95% CI, 1.02, 8.33) had significantly higher odds of seropositivity. Vaccination (OR, 0.05; 95% CI, 0.02, 0.12) and face mask use (OR, 0.36; 95% CI, 0.17, 0.78) were protective.Conclusions:The seroconversion and seroreversion rates were low among participants. Public health and infection prevention measures implemented early in the COVID-19 pandemic – vaccination, face mask use, and social distancing – were associated with significantly lower odds of SARS-CoV-2 seropositivity among participants.
Details
- Title: Subtitle
- SARS-CoV-2 seropositivity among healthcare professionals in a rural state
- Creators
- Brianna Wright - University of Iowa, Internal MedicineDaniel Kang - University of IowaAllison Schuette - University of IowaMelissa Ward - University of IowaMatthew Krasowski - University of IowaAaron Scherer - University of IowaDaniel Diekema - University of IowaJoseph Cavanaugh - University of IowaLoreen Herwaldt - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Antimicrobial stewardship & healthcare epidemiology : ASHE, Vol.4(1), e190
- DOI
- 10.1017/ash.2024.420
- PMID
- 39465214
- PMCID
- PMC11505257
- NLM abbreviation
- Antimicrob Steward Healthc Epidemiol
- eISSN
- 2732-494X
- Publisher
- Cambridge University Press
- Grant note
- Stead Family Children's Hospital
The authors thank our fellow University of Iowa Health Care, Stead Family Children's Hospital, and Carver College of Medicine colleagues, without whose generous participation this work would not be possible.
- Language
- English
- Date published
- 10/01/2024
- Academic Unit
- Statistics and Actuarial Science; Infectious Diseases; Epidemiology; Pathology; Biostatistics; Injury Prevention Research Center; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984738165502771
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