Journal article
SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity
Diabetes (New York, N.Y.), Vol.67(11), pp.2213-2226
11/2018
DOI: 10.2337/db17-1538
PMCID: PMC6198345
PMID: 30104247
Abstract
AMPK is a cellular gauge that is activated under conditions of low energy, increasing energy production and reducing energy waste. Current evidence links hypothalamic AMPK with the central regulation of energy balance. However, it is unclear whether targeting hypothalamic AMPK has beneficial effects in obesity. Here, we show that genetic inhibition of AMPK in the ventromedial nucleus of the hypothalamus (VMH) protects against high-fat diet (HFD)-induced obesity by increasing brown adipose tissue (BAT) thermogenesis and subsequently energy expenditure. Notably, this effect depends upon the AMPKα1 isoform in steroidogenic factor 1 (SF1) neurons of the VMH, since mice bearing selective ablation of AMPKα1 in SF1 neurons display resistance to diet-induced obesity, increased BAT thermogenesis, browning of white adipose tissue, and improved glucose and lipid homeostasis. Overall, our findings point to hypothalamic AMPK in specific neuronal populations as a potential druggable target for the treatment of obesity and associated metabolic disorders.
Details
- Title: Subtitle
- SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity
- Creators
- Patricia Seoane-Collazo - CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, SpainJuan Roa - Department of Cell Biology, Physiology and Immunology, University of Córdoba, Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Universitario Reina Sofía, Córdoba, SpainEva Rial-Pensado - CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, SpainLaura Liñares-Pose - CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, SpainDaniel Beiroa - CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, SpainFrancisco Ruíz-Pino - Department of Cell Biology, Physiology and Immunology, University of Córdoba, Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Universitario Reina Sofía, Córdoba, SpainTania López-González - CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, SpainDonald A Morgan - Department of Pharmacology, University of Iowa, Iowa City, IAJosé Ángel Pardavila - Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, SpainMaría Jesús Sánchez-Tapia - Department of Cell Biology, Physiology and Immunology, University of Córdoba, Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Universitario Reina Sofía, Córdoba, SpainNoelia Martínez-Sánchez - CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, SpainCristina Contreras - CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, SpainMiguel Fidalgo - Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, SpainCarlos Diéguez - CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, SpainRoberto Coppari - Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, SwitzerlandKamal Rahmouni - Department of Internal Medicine, University of Iowa, Iowa City, IARubén Nogueiras - CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, SpainManuel Tena-Sempere - FiDiPro Program, Institute of Biomedicine, University of Turku, Turku, FinlandMiguel López - CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
- Resource Type
- Journal article
- Publication Details
- Diabetes (New York, N.Y.), Vol.67(11), pp.2213-2226
- Publisher
- United States
- DOI
- 10.2337/db17-1538
- PMID
- 30104247
- PMCID
- PMC6198345
- ISSN
- 0012-1797
- eISSN
- 1939-327X
- Grant note
- P01 HL084207 / NHLBI NIH HHS
- Language
- English
- Date published
- 11/2018
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040358302771
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