Journal article
SIR-Spheres activity measurements reveal systematic miscalibration
The Journal of nuclear medicine (1978), Vol.63(8), pp.1131-1135
01/06/2022
DOI: 10.2967/jnumed.121.262650
PMID: 34992155
Abstract
The purpose of this work was to perform an independent and National Institute of Standards and Technology–traceable activity measurement of 90Y SIR-Spheres (Sirtex). g-spectroscopic measurements of the 90Y internal pair production decay mode were made using a high-purity germanium detector. Methods: Measured annihilation radiation detection rates were corrected for radioactive decay during acquisition, dead time, source attenuation, and source geometry effects. Detection efficiency was determined by 2 independent and National Institute of Standards and Technology–traceable methods. Results: Measured SIR-Spheres vials (n 5 5) contained more activity than specified by the manufacturer calibration; on average, the ratio of measured activity to calibrated was 1.233 6 0.030. Activity measurements made using 2 distinct efficiency calibration methods agreed within 1%. Conclusion: The primary SIR-Spheres activity calibration appears to be a significant underestimate of true activity.
Details
- Title: Subtitle
- SIR-Spheres activity measurements reveal systematic miscalibration
- Creators
- Stephen A Graves - University of IowaMolly Martin - University of IowaAshok Tiwari - University of IowaMichael J Merrick - University of IowaJohn J Sunderland - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of nuclear medicine (1978), Vol.63(8), pp.1131-1135
- DOI
- 10.2967/jnumed.121.262650
- PMID
- 34992155
- NLM abbreviation
- J Nucl Med
- ISSN
- 0161-5505
- eISSN
- 1535-5667
- Language
- English
- Date published
- 01/06/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Physics and Astronomy; Radiation Oncology; Pharmacy Practice and Science
- Record Identifier
- 9984312972202771
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