Journal article
SNP fine mapping of chromosome 8q24 in bipolar disorder
American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.144(5), pp.625-630
2007
DOI: 10.1002/ajmg.b.30486
PMID: 17357146
Abstract
We previously reported linkage to chromosome 8q24 in bipolar disorder (BP) with a LOD of 3.32. We fine mapped the locus with SNPs and tested for association with BP in families with evidence of linkage to the region. We genotyped 249 informative SNPs over 3.4 Mb in an initial sample of 155 nuclear families (352 affected offsprings), and followed up the best findings by genotyping six of the most significantly associated SNPs in a replication sample of 103 nuclear families (231 affected offsprings). We used FBAT and GIST for association tests. Two clusters of SNPs emerged with the strongest evidence of association. The first consisted of three SNPs, approximately 3 kb 5′ from the gene ST3GAL1. These SNPs were associated with BP in the initial sample by FBAT (best P = 0.001) and GIST (best P = 0.05) and associated in the replication sample by FBAT (best P = 0.04). The second cluster consisted of four SNPs (one of which was not genotyped in the replication sample), approximately 480 kb 5′ of ST3GAL1 in a relative gene desert. These SNPs were associated with BP in the initial sample by FBAT (best P = 0.007) and GIST (best P = 0.03), and marginally associated in the replication sample by FBAT (best P = 0.07) and GIST (P = 0.04). ST3GAL1 belongs to a family of glycosyltransferase proteins, several members of which are highly expressed in the brain and involved in neurogenesis. Several other interesting candidate genes are also located nearby. The congruence of findings across methods and samples suggests further investigation is warranted in these two targeted regions
Details
- Title: Subtitle
- SNP fine mapping of chromosome 8q24 in bipolar disorder
- Creators
- Peter P ZANDI - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United StatesDimitrios AVRAMOPOULOS - Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, United StatesVirginia L WILLOUR - Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, United StatesYuqing Huo - Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, United StatesKuangyi Miao - Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, United StatesDean F MACKINNON - Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, United StatesMelvin G MCLNNIS - Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, United StatesJames B POTASH - Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, United StatesJ. Raymond DEPAULO - Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, United States
- Resource Type
- Journal article
- Publication Details
- American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.144(5), pp.625-630
- Publisher
- Wiley-Liss; Hoboken, N.J
- DOI
- 10.1002/ajmg.b.30486
- PMID
- 17357146
- ISSN
- 1552-4841
- eISSN
- 1552-485X
- Language
- English
- Date published
- 2007
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984070776702771
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