Journal article
SUBACUTE FOCAL ADENOVIRUS ENCEPHALITIS
Journal of neuropathology and experimental neurology, Vol.32(1), pp.34-50
01/1973
DOI: 10.1097/00005072-197301000-00003
PMID: 4346656
Abstract
Subacute adenovirus encephalitis, a hitherto undescribed neuropathologic entity, is described in a 42-year-old patient who had a malignant lymphoma and was vigorously treated with various therapeutic immunosuppressive measures during the terminal five years of his illness. The patient developed altered consciousness and convulsions one month prior to death. Focal necrosis mimicking an old cystic encephalomalacia was noted in the left occipital lobe.Characteristic histopathologic features were 1) gigantic basophilic nuclear inclusions of cortical neurons, 2) extensive subpial mineralization, 3) marked astrogliosis and microgliosis, 4) petechial hemorrhages, and 5) perivascular lymphocytic infiltrates. Electron-microscopy revealed numerous viral particles and crystalline arrays within the nuclear inclusions characteristic of adeno-virus. Identification of adenovirus was substantiated by the immunofluorescent method and the presence of 252 capsomeres per virion with negative stain technique. An adenovirus closely related with adenovirus type 32 was isolated from the frozen brain tissue.
Details
- Title: Subtitle
- SUBACUTE FOCAL ADENOVIRUS ENCEPHALITIS
- Creators
- S CHOU - National Institute of Neurological Diseases and Stroke, NIH, Bethesda, Maryland 21104R ROOSR BURRELLL GUTMANNJ HARLEY
- Resource Type
- Journal article
- Publication Details
- Journal of neuropathology and experimental neurology, Vol.32(1), pp.34-50
- DOI
- 10.1097/00005072-197301000-00003
- PMID
- 4346656
- NLM abbreviation
- J Neuropathol Exp Neurol
- ISSN
- 0022-3069
- eISSN
- 1554-6578
- Publisher
- American Association of Neuropathologists, Inc
- Language
- English
- Date published
- 01/1973
- Academic Unit
- Neurology
- Record Identifier
- 9984020796902771
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