Journal article
SUPERFICIAL BLADDER CANCER: THE ROLE OF INTERFERON-alpha
The Journal of urology, Vol.159(6), pp.1793-1801
06/1998
DOI: 10.1016/S0022-5347(01)63160-4
PMID: 9598463
Abstract
Purpose: We evaluate the clinical experience with recombinant interferon-α in superficial transitional cell carcinoma and discuss the most rational use of recombinant interferon-α in the context of current treatment options. Materials and Methods: The available data were reviewed and discussed at a consensus conference in August 1996. The conclusions and recommendations are those of the authors based on the consensus reached at that meeting. Results: While bacillus Calmette-Guerin (BCG) is recognized as the most efficacious intravesical agent in the prophylaxis and treatment of superficial transitional cell carcinoma, it is associated with significant toxicities and a 20 to 40% relapse rate. Interferons, particularly recombinant interferon-α, have demonstrated efficacy against primary and recurrent papillary transitional cell carcinoma and carcinoma in situ with minimal toxicity, although the response and relapse rates are inferior to BCG. Intravesical recombinant interferon-α therapy has also produced responses in patients who failed to respond or were refractory to BCG or chemotherapy. Conclusions: The clinical experience suggests that recombinant interferon-α has an important role in the treatment of superficial transitional cell carcinoma, particularly as second line therapy following failure of BCG or chemotherapy, and it may have synergistic effects when combined with chemotherapy or BCG. We propose a prospective randomized study comparing the efficacy of recombinant interferon-α, BCG and BCG plus recombinant interferon-α as maintenance following complete response to primary BCG therapy. The proposed study would also investigate the efficacy of BCG plus recombinant interferon-α as second line therapy following BCG failure. This study will be important to determine the most effective strategy to integrate recombinant interferon-α into current treatment options for superficial bladder cancer.
Details
- Title: Subtitle
- SUPERFICIAL BLADDER CANCER: THE ROLE OF INTERFERON-alpha
- Creators
- ARIE S. Belldegrun - University of California, Los AngelesJOHN R. Franklin - Beth Israel Deaconess Medical CenterMICHAEL A. O'DONNELL - Thomas Jefferson UniversityLEONARD G. Gomella - Beth Israel Deaconess Medical CenterERIC Klein - Beth Israel Deaconess Medical CenterRUDOLPH Neri - Beth Israel Deaconess Medical CenterUNYIME O. Nseyo - Beth Israel Deaconess Medical CenterTIMOTHY L. Ratliff - Beth Israel Deaconess Medical CenterRICHARD D. Williams - Beth Israel Deaconess Medical Center
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.159(6), pp.1793-1801
- DOI
- 10.1016/S0022-5347(01)63160-4
- PMID
- 9598463
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Language
- English
- Date published
- 06/1998
- Academic Unit
- Urology
- Record Identifier
- 9984319974202771
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