SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans

Sarit Smolikov; Andreas Eizinger; Kristina Schild-Prufert; Allison Hurlburt; Kent McDonald; JoAnne Engebrecht; Anne M Villeneuve; Mónica P Colaiácovo

doi:10.1534/genetics.107.072413

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SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans

Journal article

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Peer reviewed

SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans

Sarit Smolikov, Andreas Eizinger, Kristina Schild-Prufert, Allison Hurlburt, Kent McDonald, JoAnne Engebrecht, Anne M Villeneuve and Mónica P Colaiácovo

Genetics (Austin), Vol.176(4), pp.2015-2025

08/2007

DOI: 10.1534/genetics.107.072413

PMCID: PMC1950610

PMID: 17565948

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Abstract

Synaptonemal complex (SC) formation must be regulated to occur only between aligned pairs of homologous chromosomes, ultimately ensuring proper chromosome segregation in meiosis. Here we identify SYP-3, a coiled-coil protein that is required for assembly of the central region of the SC and for restricting its loading to occur only in an appropriate context, forming structures that bridge the axes of paired meiotic chromosomes in Caenorhabditis elegans. We find that inappropriate loading of central region proteins interferes with homolog pairing, likely by triggering a premature change in chromosome configuration during early prophase that terminates the search for homologs. As a result, syp-3 mutants lack chiasmata and exhibit increased chromosome mis-segregation. Altogether, our studies lead us to propose that SYP-3 regulates synapsis along chromosomes, contributing to meiotic progression in early prophase.

DNA, Helminth - genetics

Meiosis - physiology

Caenorhabditis elegans - genetics

Synaptonemal Complex - physiology

Genes, Helminth

DNA Primers - genetics

Chromosome Pairing - genetics

Synaptonemal Complex - genetics

Synaptonemal Complex - ultrastructure

Caenorhabditis elegans - physiology

Caenorhabditis elegans - ultrastructure

Chromosome Pairing - physiology

Meiosis - genetics

Animals

Base Sequence

Chromosome Segregation - physiology

Caenorhabditis elegans Proteins - physiology

Models, Genetic

Mutation

Caenorhabditis elegans Proteins - genetics

Chromosome Segregation - genetics

Details

Title: Subtitle: SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans
Creators: Sarit Smolikov - Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Andreas Eizinger
Kristina Schild-Prufert
Allison Hurlburt
Kent McDonald
JoAnne Engebrecht
Anne M Villeneuve
Mónica P Colaiácovo
Resource Type: Journal article
Publication Details: Genetics (Austin), Vol.176(4), pp.2015-2025
DOI: 10.1534/genetics.107.072413
PMID: 17565948
PMCID: PMC1950610
NLM abbreviation: Genetics
ISSN: 0016-6731
eISSN: 1943-2631
Publisher: United States
Grant note: R01 GM053804 / NIGMS NIH HHS R01 GM 072551 / NIGMS NIH HHS R01 GM 53804 / NIGMS NIH HHS R01 GM072551 / NIGMS NIH HHS
Language: English
Date published: 08/2007
Academic Unit: Biology
Record Identifier: 9983991991702771

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