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Saccharomyces cerevisiae Multidrug Resistance Gene Expression Inversely Correlates with the Status of the F0Component of the Mitochondrial ATPase
Journal article   Open access   Peer reviewed

Saccharomyces cerevisiae Multidrug Resistance Gene Expression Inversely Correlates with the Status of the F0Component of the Mitochondrial ATPase

Xiaoting Zhang and W. Scott Moye-Rowley
The Journal of biological chemistry, Vol.276(51), pp.47844-47852
12/2001
DOI: 10.1074/jbc.M106285200
PMID: 11602584
url
https://doi.org/10.1074/jbc.M106285200View
Published (Version of record) Open Access

Abstract

Loss of the mitochondrial genome (ρ0 cell) or elimination of the mitochondrial inner membrane protein Oxa1p causes a dramatic increase in expression of the ATP binding cassette transporter-encoding gene PDR5 in the yeast Saccharomyces cerevisiae. This increase in gene expression occurs via activation of the function of the Cys6-Zn(II)2 cluster transcription factor Pdr3p, which in turn autoregulates expression of its structural gene. Surprisingly, the acquisition of PDR5-dependent multidrug resistance occurs at a very high frequency, consistent with the appearance of ρ- cells in a fermentatively growing culture (∼2%). The degree of activation of Pdr3p target genes was found to vary considerably and to be influenced by the presence of the homologous protein, Pdr1p. Mutagenesis and overexpression studies provided evidence that the control of Pdr3p expression was the major control point of this transcription factor by mitochondrial retrograde signaling. Because both ρ0 and oxa1 mutant cells have multiple defects including loss of normal respiratory chain function and oxidative phosphorylation, a series of mutant strains with more selective defects in mitochondrial function was employed to identify the molecular signal that triggers PDR5 transcriptional activation. Only mutations that influenced the functional status of the F0 subunit of the mitochondrial ATPase were found to lead to activation of PDR5 expression.

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