Safe conception for HIV-discordant couples: insemination with processed semen from the HIV-infected partner

Augusto Enrico Semprini; Maurizio Macaluso; Lital Hollander; Alessandra Vucetich; Ann Duerr; Gil Mor; Marina Ravizza; Denise J. Jamieson

doi:10.1016/j.ajog.2013.02.009

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Safe conception for HIV-discordant couples: insemination with processed semen from the HIV-infected partner

Journal article

Open access

Peer reviewed

Safe conception for HIV-discordant couples: insemination with processed semen from the HIV-infected partner

Augusto Enrico Semprini, Maurizio Macaluso, Lital Hollander, Alessandra Vucetich, Ann Duerr, Gil Mor, Marina Ravizza and Denise J. Jamieson

American journal of obstetrics and gynecology, Vol.208(5), pp.402.e1-402.e9

05/01/2013

DOI: 10.1016/j.ajog.2013.02.009

PMID: 23395921

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Abstract

The objective of the study was to evaluate the safety of semen washing with intrauterine insemination (SW-IUI) for achieving pregnancy when the man is human immunodeficiency virus (HIV) infected and the woman is HIV negative. We conducted a retrospective analysis of 635 HIV-discordant couples enrolled in a SW-IUI program and followed up 367 Italian women. We computed pregnancy, live birth, and multiple delivery rates and assessed the women's postinsemination HIV status. The retrospective analysis included 635 couples (2113 SW-IUI cycles): 41% of the women (95% confidence interval [CI], 37–45%) had a live birth (per-cycle live birth rate 13%; 95% CI, 11–14%). HIV status after SW-IUI was negative when available but unknown for 26% of the women: missing HIV status was not associated with correlates of HIV risk. The follow-up study included 367 couples (1365 cycles): 47% of the women (95% CI, 42–52%) had a live birth (per-cycle rate 14%; 95% CI, 12–16%). Ascertainment of postinsemination HIV status was complete and confirmed no HIV transmission attributable to SW-IUI. The upper 95% confidence limit of the HIV transmission rate was 1.8 per 1000 cycles in the retrospective analysis and 2.7 per 1000 cycles in the follow-up study. SW-IUI appears to be a safe and effective method for achieving pregnancy in HIV-discordant couples in which the man is HIV infected.

assisted reproduction

effectivenes

follow-up studies

human immunodeficiency virus transmission

safety

Details

Title: Subtitle: Safe conception for HIV-discordant couples: insemination with processed semen from the HIV-infected partner
Creators: Augusto Enrico Semprini - Esman Medical Consulting, Milan, Italy
Maurizio Macaluso - Centers for Disease Control and Prevention
Lital Hollander - FIT Consulting (Italy)
Alessandra Vucetich - FIT Consulting (Italy)
Ann Duerr - Centers for Disease Control and Prevention
Gil Mor - FIT Consulting (Italy)
Marina Ravizza - Ospedale San Paolo
Denise J. Jamieson - Centers for Disease Control and Prevention
Resource Type: Journal article
Publication Details: American journal of obstetrics and gynecology, Vol.208(5), pp.402.e1-402.e9
DOI: 10.1016/j.ajog.2013.02.009
PMID: 23395921
NLM abbreviation: Am J Obstet Gynecol
ISSN: 0002-9378
eISSN: 1097-6868
Publisher: Mosby, Inc
Grant note: HRN-A-00-98-00020-00 / United States Agency for International Development
Language: English
Date published: 05/01/2013
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446556602771

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